PXD030017 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic analysis of Caenorhabditis elegans challenged with pseudomonas aeruginosa and the inhibitory effects of 6-methycoumarine |
Description | Goal of the analysis was to identify proteomic changes in Caenorhabditis elegans upon infection with Pseudomonas aeruginosa PA01 and to compare to inhibitory effects of virulence factor inhibitor methycoumarine. Worms grown on media containing E. coli OP50 served as control. This was achieved through tandem mass-tags based quantitative proteomics approach coupled to LC-MS/MS methods. An Orbitrap Fusion Tribrid mass spectrometer (Thermo Fischer Scientific, Bremen, Germany) connected to the Easy- nLC-1200 nanoflow liquid chromatography system (Thermo Scientific) was used for data acquisition. |
HostingRepository | PRIDE |
AnnounceDate | 2024-07-15 |
AnnouncementXML | Submission_2024-07-14_23:00:51.400.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Keshava Prasad T. S. |
SpeciesList | scientific name: Caenorhabditis elegans; NCBI TaxID: 6239; |
ModificationList | TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-11-28 06:09:20 | ID requested | |
⏵ 1 | 2024-07-14 23:00:52 | announced | |
Publication List
Ramesh P, Bajire SK, Kanichery A, Najar MA, Shastry RP, Prasad TSK, 6-Methylcoumarin rescues bacterial quorum sensing induced ribosome-inactivating stress in Caenorhabditis elegans. Microb Pathog, 173(Pt A):105833(2022) [pubmed] |
10.1016/j.micpath.2022.105833; |
Keyword List
submitter keyword: Quantitative proteomics, TMT, 7-methyl coumarine, Pseudomonas aeruginosa PAO1, Caenorhabditis elegans |
Contact List
T. S.S Keshava Prasad |
contact affiliation | Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, India |
contact email | keshav@yenepoya.edu.in |
lab head | |
Keshava Prasad T. S. |
contact affiliation | Institute of Bioinformatics, Bangalore, Karnataka, India. |
contact email | keshav@ibioinformatics.org |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD030017
- Label: PRIDE project
- Name: Proteomic analysis of Caenorhabditis elegans challenged with pseudomonas aeruginosa and the inhibitory effects of 6-methycoumarine