PXD029889-1
PXD029889 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Effect of chlorpyrifos on the expression and regulation of salivary gland protein of Haemaphysalis longicornis |
| Description | Haemaphysalis longicornis is a parasitic arthropod on the body surface of vertebrates, which lives by sucking host blood. In addition, H. longicornis can carry and transmit a variety of deadly pathogens to the host. The control of ticks mainly depends on chemical insecticides, among which chlorpyrifos is a common drug to control them. The salivary gland is an important organ to promote the blood-sucking of ticks and regulate the development of ticks, meanwhile, it plays an important role in protecting against pesticides. With the increasing drug resistance of ticks to chlorpyrifos and the harm of the drug to the environment, it is urgent to find other drugs with low toxicity and high efficiency to replace chlorpyrifos. In this study, DIA quantitative proteomics was used to study the dynamic changes of all proteins in the salivary gland of H. longicornis treated with chlorpyrifos. Bioinformatics analysis was used to analyze these proteins, and a variety of proteins that may be involved in the detoxification process were found, such as glutathione S-transferase, glutamine synthase and a variety of heat shock proteins, which provided new molecular targets and ideas for the development of anti-tick vaccines and related drugs. |
| HostingRepository | iProX |
| AnnounceDate | 2021-11-24 |
| AnnouncementXML | Submission_2021-11-23_19:14:01.156.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Ningmei Wang |
| SpeciesList | scientific name: Haemaphysalis longicornis; NCBI TaxID: 44386; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2021-11-23 19:13:26 | ID requested | |
| ⏵ 1 | 2021-11-23 19:14:01 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Haemaphysalis longicornis |
| Salivary glands |
| Chlorpyrifos |
| Quantitative proteomics |
Contact List
| Hui Wang | |
|---|---|
| contact affiliation | Hebei Normal University |
| contact email | whui1981@163.com |
| lab head | |
| Ningmei Wang | |
| contact affiliation | Hebei Normal University |
| contact email | 767247571@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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