PXD029873-2
PXD029873 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | 10-HDA reduces the hydroxyl free radical-induced damage to vascular smooth muscle cells by rescuing protein and energy metabolisms |
Description | 10-hydroxydec-2-enoic acid (10-HDA), a natural agent from royal jelly, could fight against cell and tissue damage, yet the underlying mechanisms are still unexplored. Here, we found the scavenging rate of hydroxyl free radical (•OH) by 2% (g/mL) 10-HDA was more than 20%, which was achieved by a multiple-step oxidization of the −OH group and C=C bond in 10-HDA. Moreover, 10-HDA could enhance the viability of vascular smooth muscle cells (VSMCs) damaged by •OH, indicating its role in reducing the •OH-induced cytotoxicity. The 195 proteins decreased by •OH challenge in VSMCs were up-regulated by 10-HDA rescue, which mainly elevated the activities of protein and energy metabolisms within nucleus and cytoplasm. These evidences indicate that 10-HDA plays key roles in promoting cell survival through antagonizing •OH-induced injury in VSMCs. Our results provide the first solid evidence that 10-HDA scavenging •OH could be a potential pharmacological application in keeping vascular health. |
HostingRepository | iProX |
AnnounceDate | 2021-11-22 |
AnnouncementXML | Submission_2023-12-21_22:04:30.001.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Bin Han |
SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2021-11-22 19:24:48 | ID requested | |
1 | 2021-11-22 19:25:08 | announced | |
⏵ 2 | 2023-12-21 22:04:30 | announced | 2023-12-22: Update information. |
Publication List
Fan P, Sha F, Ma C, Wei Q, Zhou Y, Shi J, Fu J, Zhang L, Han B, Li J, 10-Hydroxydec-2-Enoic Acid Reduces Hydroxyl Free Radical-Induced Damage to Vascular Smooth Muscle Cells by Rescuing Protein and Energy Metabolism. Front Nutr, 9():873892(2022) [pubmed] |
Keyword List
submitter keyword: 10-hydroxydec-2-enoic acid, hydroxyl free radical, vascular smooth muscle cell, cytotoxicity, proteomics |
Contact List
Shufa Xu | |
---|---|
contact affiliation | Institute of Apicultural Research, Chinese Academy of Agricultural Sciences |
contact email | xushufa@caas.cn |
lab head | |
Bin Han | |
contact affiliation | Institute of Apicultural Research, Chinese Academy of Agricultural Sciences |
contact email | hanbin@caas.cn |
dataset submitter |
Full Dataset Link List
iProX dataset URI |