PXD029756-1
PXD029756 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Protein Posttranslational Signatures Identified in COVID-19 Patient Plasma |
| Description | Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a highly contagious virus of the coronavirus family that causes coronavirus disease-19 (COVID-19) in humans and a number of animal species. COVID-19 has rapidly propagated in the world in the past 2 years, causing a global pandemic. Here, we performed proteomic analysis of plasma samples from COVID-19 patients compared to healthy control donors in an exploratory study to gain insights into protein-level changes in the patients caused by SARS-CoV-2 infection and to identify potential proteomic and posttranslational signatures of this disease. Our results suggest a global change in protein processing and regulation that occurs in response to SARS-CoV-2, and the existence of a posttranslational COVID-19 signature that includes an elevation in threonine phosphorylation, a change in glycosylation, and a decrease in arginylation, an emerging posttranslational modification not previously implicated in infectious disease. This study provides a resource for COVID-19 researchers and, longer term, will inform our understanding of this disease and its treatment. |
| HostingRepository | MassIVE |
| AnnounceDate | 2022-08-24 |
| AnnouncementXML | Submission_2022-08-24_06:45:00.572.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Hsin-Yao Tang |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | Oxidation; Phospho; Acetyl; Deamidated; N-methyl arginyl |
| Instrument | Q Exactive HF; Q Exactive Plus |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2021-11-15 10:22:47 | ID requested | |
| ⏵ 1 | 2022-08-24 06:45:00 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: COVID-19, Protein Posttranslational Signatures |
Contact List
| Anna Kashina | |
|---|---|
| contact affiliation | Department of Biomedical Sciences, University of Pennsylvania School of Veterinary Medicine |
| contact email | akashina@upenn.edu |
| lab head | |
| Hsin-Yao Tang | |
| contact affiliation | The Wistar Institute |
| contact email | tangh@wistar.org |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000088382/ |
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