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PXD029745-1

PXD029745 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleNAD metabolism modulates mitochondrial function and inflammation and prevents progression of diabetic kidney disease
DescriptionBackground: Diabetes mellitus is the leading cause of cardiovascular and renal disease in the United States. In spite of all of the beneficial interventions implemented in patients with diabetes, there remains a need for additional therapeutic targets in diabetic kidney disease (DKD). Mitochondrial dysfunction and inflammation are increasingly recognized as important causes of the development and progression of DKD. However, the molecular connection between mitochondrial function, inflammation, and fibrosis remains to be elucidated. Methods: In the present studies we tested the hypothesis that enhancing NAD metabolism could increase mitochondrial sirtuin 3 (SIRT3) activity, improve mitochondrial function, decrease mitochondrial DNA damage, and prevent inflammation and progression of DKD. Results: We found that treatment of db-db mice with type 2 diabetes with nicotinamide riboside (NR) prevented albuminuria, increased urinary KIM1 excretion, and several parameters of DKD. These effects were associated with increased SIRT3 activity, improved mitochondrial function, and decreased inflammation at least in part via inhibiting the activation of the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) signaling pathway. Conclusions: NR supplementation boosted the NAD metabolism to modulate mitochondrial function and inflammation and prevent progression of diabetic kidney disease.
HostingRepositoryPRIDE
AnnounceDate2023-08-02
AnnouncementXMLSubmission_2023-08-02_09:27:34.300.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJuliaPanov
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-11-15 06:26:54ID requested
12023-08-02 09:27:34announced
22023-11-14 06:54:26announced2023-11-14: Updated project metadata.
32024-10-22 05:59:36announced2024-10-22: Updated project metadata.
Publication List
Keyword List
submitter keyword: NR, kidney,diabetes, dbdb
Contact List
MosheLevi
contact affiliationDepartment of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington, DC
contact emailmoshe.levi@georgetown.edu
lab head
JuliaPanov
contact affiliationUniversity of Haifa
contact emailjuliapanov.uni@gmail.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
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