PXD029635-1

PXD029635 is an original dataset announced via ProteomeXchange.

Title	Proteomics investigations of potential protein biomarkers in sera of rabbits infected with Schistosoma japonicum
Description	Schistosomiasis is a chronic parasitic disease that continues to be a pressing public health problem in many developing countries. The primary pathological damage from the disease is granuloma and fibrosis caused by egg aggregation, and early treatment can effectively prevent the occurrence of liver fibrosis. Therefore, it is very important to identify biomarkers that can be used for early diagnosis of Schistosoma japonicum infection. In this study, a label-free proteomics method was performed to observe the alteration of proteins before infection, 1 week, and 6 weeks after infection, as well as 5 weeks and 7 weeks after treatment. A total of 10 proteins derived from S. japonicum and 242 host-derived proteins were identified and quantified as significantly changed. Temporal analysis was carried out to further analyze potential biomarkers with coherent changes during infection and treatment. The results revealed biological process changes in serum proteins compared to infection and treatment groups, which implicated receptor-mediated endocytosis, inflammatory response, and acute-phase response such as Mannan binding lectin serine peptidase 1, immunoglobulin, and phosphoglycerate mutase. These findings offer guidance for in-depth analysis of potential biomarkers of Schistosomiasis, host protein, and early diagnosis of S. japonica and its pathogenesis.
HostingRepository	PRIDE
AnnounceDate	2021-12-20
AnnouncementXML	Submission_2021-12-20_11:48:25.974.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Nian-Nian Bi
SpeciesList	scientific name: Oryctolagus cuniculus; NCBI TaxID: 9986;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2021-11-09 06:07:57	ID requested
⏵ 1	2021-12-20 11:48:26	announced

Dataset with its publication pending

submitter keyword: Schistosoma japonicum, proteomics, label free, biomarker, bioinformatics

Kun Yang
contact affiliation	Key Laboratory of National Health and Family Planning Commission on Parasitic Disease Control and Pre-vention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, 117 Meiyuan Yangxiang, Wuxi 214064, Jiangsu, China.
contact email	yangkun@jipd.com
lab head
Nian-Nian Bi
contact affiliation	Nanjing Medical University
contact email	mylmbnn@163.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD029635
     1. Label: PRIDE project
     2. Name: Proteomics investigations of potential protein biomarkers in sera of rabbits infected with Schistosoma japonicum