PXD029388-2

PXD029388 is an original dataset announced via ProteomeXchange.

Title	Quantitative proteomics revealed the mechanism of Yiqi Huoxue recipe used to treat cerebral infarction with Qi deficiency and blood stasis
Description	Huoxue Yiqi (HXYQ) recipe is widely used to treat cerebral infarction with Qi deficiency and blood stasis syndrome (CI-QDBS), but its pharmacological mechanism is still not clear. In this study, the serum samples of patients with Qi deficiency and blood stasis syndrome in the convalescent stage of cerebral infarction were used as the research object. The protein expression levels among the control group, Yiqi group and Huoxue Yiqi group were compared by non labeled quantitative proteomics technology. The difference of protein expression level was higher than 1.2 times as the significant difference. Compared with the control group, there were 120 differentially expressed proteins; Through bioinformatics analysis and biological function clustering of differentially expressed proteins, it is found that Yiqi recipe can regulate energy metabolism and nerve function and change hemorheology, while Yiqi Huoxue recipe can regulate energy metabolism, antithrombotic function and improve vascular function. This study explored the biological mechanism of Yiqi recipe and Huoxue Yiqi recipe in the protein level, which provided a molecular basis for the clinical treatment of CI-QDBS and the related research of traditional Chinese medicine.
HostingRepository	iProX
AnnounceDate	2022-12-12
AnnouncementXML	Submission_2022-12-12_01:37:24.613.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ying Li
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2021-10-27 22:15:32	ID requested
1	2021-10-27 22:16:31	announced
⏵ 2	2022-12-12 01:37:24	announced	2022-12-12: Update information.
3	2023-07-03 20:43:59	announced	2022-12-12: Update information. 2023-07-04: Update publication information.

Dataset with its publication pending

submitter keyword: cerebral infarction, Qi deficiency and blood stasis syndrome, Proteomics, Huoxue Yiqi recipe

Ying Li
contact affiliation	Institute of Basic Medical Sciences, Xiyuan Hospital, China Academy of Chinese Medical Sciences
contact email	yingli0815@163.com
lab head
Ying Li
contact affiliation	Institute of Basic Medical Sciences, Xiyuan Hospital, China Academy of Chinese Medical Sciences
contact email	yingli0815@163.com
dataset submitter

iProX dataset URI