PXD029341-1

PXD029341 is an original dataset announced via ProteomeXchange.

Title	The IPF fibroblastic focus is an active collagen biosynthesis factory embedded in a distinct extracellular matrix
Description	The Fibroblastic Focus (FF) is a lesion typical of Idiopathic Pulmonary Fibrosis (IPF). It is the site of myofibroblast accumulation and extracellular matrix (ECM) production. The molecular composition and function of the FF and surrounding tissue remain undefined. Utilizing laser capture microdissection coupled mass spectrometry (LCM-MS), we interrogate the FF, adjacent mature scar tissue, and adjacent alveoli in 6 IPF specimens. To serve as a control, we perform LCM-MS on alveoli from 6 non-fibrotic controls.
HostingRepository	PRIDE
AnnounceDate	2022-08-31
AnnouncementXML	Submission_2022-08-31_04:52:46.392.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Craig Lawless
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-10-25 06:48:20	ID requested
⏵ 1	2022-08-31 04:52:47	announced

Herrera JA, Dingle L, Montero MA, Venkateswaran RV, Blaikley JF, Lawless C, Schwartz MA, The UIP/IPF fibroblastic focus is a collagen biosynthesis factory embedded in a distinct extracellular matrix. JCI Insight, 7(16):(2022) [pubmed]

submitter keyword: Human, IPF, Collagen, fibroblastic focus

Jeremy Herrera
contact affiliation	The Wellcome Centre for Cell-Matrix Research, University of Manchester, Manchester, UK
contact email	Jeremy.Herrera@manchester.ac.uk
lab head
Craig Lawless
contact affiliation	University of Manchester
contact email	craig.lawless@manchester.ac.uk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD029341
     1. Label: PRIDE project
     2. Name: The IPF fibroblastic focus is an active collagen biosynthesis factory embedded in a distinct extracellular matrix