PXD029341 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | The IPF fibroblastic focus is an active collagen biosynthesis factory embedded in a distinct extracellular matrix |
Description | The Fibroblastic Focus (FF) is a lesion typical of Idiopathic Pulmonary Fibrosis (IPF). It is the site of myofibroblast accumulation and extracellular matrix (ECM) production. The molecular composition and function of the FF and surrounding tissue remain undefined. Utilizing laser capture microdissection coupled mass spectrometry (LCM-MS), we interrogate the FF, adjacent mature scar tissue, and adjacent alveoli in 6 IPF specimens. To serve as a control, we perform LCM-MS on alveoli from 6 non-fibrotic controls. |
HostingRepository | PRIDE |
AnnounceDate | 2022-08-31 |
AnnouncementXML | Submission_2022-08-31_04:52:46.392.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Craig Lawless |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-10-25 06:48:20 | ID requested | |
⏵ 1 | 2022-08-31 04:52:47 | announced | |
Publication List
Herrera JA, Dingle L, Montero MA, Venkateswaran RV, Blaikley JF, Lawless C, Schwartz MA, The UIP/IPF fibroblastic focus is a collagen biosynthesis factory embedded in a distinct extracellular matrix. JCI Insight, 7(16):(2022) [pubmed] |
Keyword List
submitter keyword: Human, IPF, Collagen, fibroblastic focus |
Contact List
Jeremy Herrera |
contact affiliation | The Wellcome Centre for Cell-Matrix Research, University of Manchester, Manchester, UK |
contact email | Jeremy.Herrera@manchester.ac.uk |
lab head | |
Craig Lawless |
contact affiliation | University of Manchester |
contact email | craig.lawless@manchester.ac.uk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD029341
- Label: PRIDE project
- Name: The IPF fibroblastic focus is an active collagen biosynthesis factory embedded in a distinct extracellular matrix