PXD029311-1

PXD029311 is an original dataset announced via ProteomeXchange.

Title	The potential of remdesivir to affect function, metabolism and proliferation of in vitro heart and kidney models
Description	Here, we performed an in vitro toxicity assessment for remdesivir at clinically relevant concentrations around the cmax of 9 µM using H9c2 rat cardiomyoblasts and neonatal mouse cardiomyocytes (NMCM) as heart models and rat NRK-52E cells and human RPTEC/TERT1 cells as kidney models. Due to the tendency of nucleoside analogs for mitochondrial toxicity, we focused on metabolic changes and mitochondrial function. Additionally, we analyzed the functionality of NMCM and determined early proteomic changes.
HostingRepository	PRIDE
AnnounceDate	2022-05-24
AnnouncementXML	Submission_2022-05-24_01:24:24.760.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Laxmikanth Kollipara
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2021-10-25 00:02:13	ID requested
⏵ 1	2022-05-24 01:24:25	announced

Merches K, Breunig L, Fender J, Brand T, B, ä, tz V, Idel S, Kollipara L, Reinders Y, Sickmann A, Mally A, Lorenz K, The potential of remdesivir to affect function, metabolism and proliferation of cardiac and kidney cells in vitro. Arch Toxicol, 96(8):2341-2360(2022) [pubmed]

submitter keyword: remdesivir, cardiotoxicity, nephrotoxicity, Covid-19, nucleoside analogue, mitochondrial toxicity

Prof. Dr. Albert Sickmann
contact affiliation	Leibniz-Institut für Analytische Wissenschaften – ISAS – e.V. Otto-Hahn-Straße 6b 44227 Dortmund, Germany P: +49 (0)2 31.13 92-100 F: +49 (0)2 31.13 92-200 albert.sickmann@isas.de www.isas.de twitter.com/isas_Leibniz
contact email	albert.sickmann@isas.de
lab head
Laxmikanth Kollipara
contact affiliation	Leibniz – Institut für Analytische Wissenschaften - ISAS - e.V.
contact email	laxmikanth.kollipara@isas.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/05/PXD029311

PRIDE project URI

• PRIDE
  1. PXD029311
     1. Label: PRIDE project
     2. Name: The potential of remdesivir to affect function, metabolism and proliferation of in vitro heart and kidney models