PXD029195-2

PXD029195 is an original dataset announced via ProteomeXchange.

Title	Integrative multi-omic profiling of adult mouse brain endothelial cells and potential implications in Alzheimer’s disease
Description	Blood-brain barrier (BBB) critically regulate the homeostasis of central nervous system (CNS). This barrier property allows cerebral vessels to meet the extremely high metabolic demand of neural activities and meanwhile protect sensitive neurons from toxic plasma components, blood immune cells and xenobiotics. Therefore, a comprehensive inventory of the molecular determinants of BBB would substantially facilitate understanding of the pathogenesis of neurological disorders involving BBB dysfunction and promote development of novel CNS drug delivery strategies. Here, we established the proteome activity landscapes of adult mouse brain, lung and liver ECs. In this study, we produced a comprehensive molecular atlas of adult mouse BBB and revealed novel insights into adult BBB in health and Alzheimer’s disease.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:13:39.081.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Shilun Yang
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2021-10-18 02:12:53	ID requested
1	2023-10-31 23:56:35	announced
⏵ 2	2024-10-22 06:13:39	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: brain,Mouse, DIA-MS, lung, liver, endothelial cell

Junlei Chang
contact affiliation	Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences
contact email	jl.chang@siat.ac.cn
lab head
Shilun Yang
contact affiliation	Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences
contact email	sl.yang@siat.ac.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/11/PXD029195

PRIDE project URI

• PRIDE
  1. PXD029195
     1. Label: PRIDE project
     2. Name: Integrative multi-omic profiling of adult mouse brain endothelial cells and potential implications in Alzheimer’s disease