PXD029180-1

PXD029180 is an original dataset announced via ProteomeXchange.

Title	ERBB2 signalling and functions in oesophageal cancer
Description	Oesophageal adenocarcinoma (OAC) is a deadly disease with poor survival statistics and few targeted therapies available. One of the most common molecular aberrations in OAC is amplification or activation of the receptor tyrosine kinase ERBB2, and ERBB2 is targeted in the clinic for this subset of patients. However, the downstream consequences of these activating events ERBB2 activation or amplification are not well understood. Here we used a combination of phosphoproteomics, open chromatin profiling and transcriptome analysis on cell line models and patient-derived datasets to interrogate the molecular pathways operating downstream from ERBB2. Integrated analysis of these data sets converge on a model where ERBB2 activity is mediated at the transcriptional level by the transcription factor AP1. AP1 in turn controls cell behaviour by acting on cohorts of genes that regulate cell migration and adhesion, features often associated with EMT. Our study therefore provides a valuable resource for the cancer cell signalling community and reveals novel molecular determinants underlying the dysregulated behaviour of OAC cells.
HostingRepository	PRIDE
AnnounceDate	2023-01-04
AnnouncementXML	Submission_2023-01-04_03:45:17.155.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	ChiaraFrancavilla
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-10-18 01:27:20	ID requested
⏵ 1	2023-01-04 03:45:17	announced

Dataset with its publication pending

submitter keyword: ERRB oesophageal cancer phosphoproteomics

chiarafrancavilla
contact affiliation	Division of Molecular and Cellular Function School of Biological Sciences Faculty of Biology Medicine and Health
contact email	chiara.francavilla@manchester.ac.uk
lab head
ChiaraFrancavilla
contact affiliation	University of Manchester
contact email	chiara.francavilla@manchester.ac.uk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD029180
     1. Label: PRIDE project
     2. Name: ERBB2 signalling and functions in oesophageal cancer