PXD029031-1

PXD029031 is an original dataset announced via ProteomeXchange.

Title	Canagliflozin regulates ferroptosis to ameliorate heart failure in rats with preserved ejection fraction
Description	Chronic heart failure (CHF), with whether reduced ejection fraction (HFrEF) or preserved ejection fraction (HFpEF), is the end-stage of various cardiovascular diseases and severely affects the patients’ lifespan. There has been no effective drugs to improve clinical outcomes for a long time. Sine the recent years, as a hypoglycemic drug, sodium-glucose cotransporter 2 inhibitor (SGLT2i) has aroused great attention due to it’s cardiovascular benefits. However, the underlying mechanisms remain unclear, particularly regarding ferroptosis, a newly defined mechanism of iron-dependent non-apoptotic cell death in heart failure (HF). Here, we discovered and demonstrated that ferroptosis was a key mechanism in rat model of high-salt diet-induced HF, characterized by iron overloading and lipid peroxidation, which was blocked by canagliflozin administration. These findings highlight that targeting ferroptosis serves as a cardioprotective strategy for HF prevention and canagliflozin might display cardiovascular benefits through ferroptosis mitigation.
HostingRepository	PRIDE
AnnounceDate	2022-05-20
AnnouncementXML	Submission_2022-05-19_22:41:06.923.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ma Sai
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-10-10 22:52:50	ID requested
⏵ 1	2022-05-19 22:41:08	announced

Ma S, He LL, Zhang GR, Zuo QJ, Wang ZL, Zhai JL, Zhang TT, Wang Y, Ma HJ, Guo YF, Canagliflozin mitigates ferroptosis and ameliorates heart failure in rats with preserved ejection fraction. Naunyn Schmiedebergs Arch Pharmacol, 395(8):945-962(2022) [pubmed]

submitter keyword: Canagliflozin, Sodium-glucose cotransporter 2 inhibitor, Ferroptosis, Lipid peroxidation, Heart failure

Yifang Guo
contact affiliation	Department of Geriatric Cardiology, Hebei General Hospital, No. 348 Heping Road, Xinhua District, Hebei, 050000, China.
contact email	guoyifang@hotmail.com
lab head
Ma Sai
contact affiliation	Hebei General Hospital
contact email	theylaugh@163.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/05/PXD029031

PRIDE project URI

• PRIDE
  1. PXD029031
     1. Label: PRIDE project
     2. Name: Canagliflozin regulates ferroptosis to ameliorate heart failure in rats with preserved ejection fraction