PXD029014-1

PXD029014 is an original dataset announced via ProteomeXchange.

Title	Phospho-proteomic analysis of DUSP6 deficient Caco-2 cells
Description	Dual-specificity phosphatase 6 (Dusp6)-deficiency enhances baseline colon barrier integrity and confers amelioration of dextran sulfate sodium (DSS)-induced colonic injury. DUSP6 is a phosphatase, and therefore it is plausible that DUSP6 knockout alters the phosphorylation status of other proteins. To access the protein phosphorylation landscape and functional network in DUSP6 deficient Caco-2 cells, we applied phosphopeptide enrichment and isobaric labeling strategies with MS-based proteomics, and identified 1323 phosphorylation sites on 580 phosphoproteins.
HostingRepository	PRIDE
AnnounceDate	2021-11-02
AnnouncementXML	Submission_2021-11-02_06:37:13.303.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chantal Hoi Yin Cheung
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2021-10-08 06:49:16	ID requested
⏵ 1	2021-11-02 06:37:13	announced

Dataset with its publication pending

submitter keyword: Caco-2 cells, DUSP6, colorectal adenocarcinoma, phosphoproteome

Hsueh-Fen Juan
contact affiliation	Department of Life Science, National Taiwan University, Taipei, Taiwan.
contact email	yukijuan@ntu.edu.tw
lab head
Chantal Hoi Yin Cheung
contact affiliation	national taiwan university
contact email	hycchantal@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/11/PXD029014

PRIDE project URI

• PRIDE
  1. PXD029014
     1. Label: PRIDE project
     2. Name: Phospho-proteomic analysis of DUSP6 deficient Caco-2 cells