PXD028803-1

PXD028803 is an original dataset announced via ProteomeXchange.

Title	Plasma proteomic profile of patients with tick-borne encephalitis and co-infections
Description	Despite the increasing number of patients suffering from tick-borne diseases, including tick-borne encephalitis (TBE) and Lyme disease, the mechanisms of development of these diseases and their effects on human body are still unknown. Moreover, the increasing number of cases of co-infections of these diseases additionally hampers the correct diagnosis and the application of effective therapy. Therefore, the aim of this study was to evaluate the changes in proteomic profile of human plasma induced by the development of TBE and to compare it with changes in TBE patients co-infected with other tick-borne pathogens. The results obtained by proteomic analysis using nanoLC-QExactive/MS showed that the most highly elevated groups of proteins in the plasma of TBE patients with co-infection were involved in the pro-inflammatory response and protein degradation, while the antioxidant proteins and factors responsible for protein biosynthesis were mainly down regulated. The main proteins, which expression differentiated patients with TBE from co-infected patients, such as AP-1, fumarylacetoacetase, serpin, annexin, or carbonic anhydrase 2, are involved in TBE virulence or antibacterial responses. These results were accompanied by the enhanced GSH- and 4-HNE-protein adducts formation, observed in TBE and co-infected patients on higher level than in the case of only TBE patients. In conclusion, the differences in the proteomic profiles between patients with TBE and co-infected indicate that the mechanisms of development of these diseases are diverse and, consequently, require different treatment, what is particularly important for further research, including the development of novel diagnostics tools.
HostingRepository	PRIDE
AnnounceDate	2022-05-19
AnnouncementXML	Submission_2022-05-19_15:38:14.497.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Agnieszka Gęgotek
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	carbamoylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-09-28 03:16:21	ID requested
⏵ 1	2022-05-19 15:38:15	announced

G, ę, gotek A, Moniuszko-Malinowska A, Groth M, Pancewicz S, Czupryna P, Dunaj J, Atalay S, Radziwon P, Skrzydlewska E, Plasma Proteomic Profile of Patients with Tick-Borne Encephalitis and Co-Infections. Int J Mol Sci, 23(8):(2022) [pubmed]

submitter keyword: tick-borne encephalitis

plasma

proteomic profile

protein adducts

co-infections

Lyme disease

neuroborreliosis

human granulocytic anaplasmosis;

Agnieszka Gęgotek
contact affiliation	Zakład Chemii Nieorganicznej i Analitycznej Uniwersytet Medyczny w Białymstoku Mickiewicza 2D, 15-222 Białystok
contact email	agnieszka.gegotek@umb.edu.pl
lab head
Agnieszka Gęgotek
contact affiliation	Medical University of Białystok
contact email	agnieszkagegotek@o2.pl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/05/PXD028803

PRIDE project URI

• PRIDE
  1. PXD028803
     1. Label: PRIDE project
     2. Name: Plasma proteomic profile of patients with tick-borne encephalitis and co-infections