PXD028561 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Glucose dissociates DDX21 dimers to regulate mRNA splicing and promote epidermal differentiation |
Description | We discovered that glucose directly bind to DDX21, induced the conformation change of the proteins and inhibit its helicase activity. Glucose also inhibits the dimerization of DDX21, re-localize DDX21 from nucleolus to nucleoplasm and reassemble DDX21 to RNA splicing complex. DDX21 is essential for epidermal differentiation while with normal glucose condition, DDX21 was re-localized from nucleolus to nucleoplasm, bind to splicing factors and mRNA introns more to regulate splicing of key differentiation factors and promote epidermal differentiation. |
HostingRepository | PRIDE |
AnnounceDate | 2023-01-06 |
AnnouncementXML | Submission_2023-01-05_19:34:20.354.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Yen-YuYang |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive Plus |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-09-16 07:40:21 | ID requested | |
⏵ 1 | 2023-01-05 19:34:20 | announced | |
2 | 2023-11-14 08:53:26 | announced | 2023-11-14: Updated project metadata. |
Publication List
Keyword List
submitter keyword: Proximity labeling,DDX21, splicing, glucose, BioID, epidermal differentiation |
Contact List
YinshengWang |
contact affiliation | Department of Chemistry, University of California Riverside |
contact email | yinsheng@ucr.edu |
lab head | |
Yen-YuYang |
contact affiliation | UC Riverside |
contact email | yyang227@ucr.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/01/PXD028561 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD028561
- Label: PRIDE project
- Name: Glucose dissociates DDX21 dimers to regulate mRNA splicing and promote epidermal differentiation