PXD028356 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Rat DRG CIPN versus Vehicle-treated mice_DIA-MS |
Description | Chemotherapy-induced peripheral neuropathy (CIPN) is a serious side effect of cancer treatment, often leading to cessation of therapy due to lack of adequate treatment options. In the peripheral nervous system the chemotherapeutic agent paclitaxel impairs mitochondrial function and induces vast changes in gene expression. However, changes at the protein level remain so far unexplored. Here we used an unbiased approach of quantitative proteome profiling in a clinically-relevant rat model of paclitaxel-induced peripheral neuropathy. We analysed two critical timepoints: (1) day 7, equivalent to 1 day after cessation of paclitaxel treatment, prior to neuropathy development; (2) approximately 4 weeks after paclitaxel initiation, when neuropathy has developed. |
HostingRepository | PRIDE |
AnnounceDate | 2022-03-24 |
AnnouncementXML | Submission_2022-03-24_04:32:39.906.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Christin Kappert |
SpeciesList | scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116; |
ModificationList | monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-09-09 08:28:40 | ID requested | |
⏵ 1 | 2022-03-24 04:32:40 | announced | |
2 | 2022-04-07 08:48:19 | announced | 2022-04-07: Updated project metadata. |
3 | 2023-11-14 08:55:07 | announced | 2023-11-14: Updated project metadata. |
Publication List
Keyword List
submitter keyword: rat, DIA-MS, DRG-Proteome, CIPN, HF-X |
Contact List
Manuela Schmidt |
contact affiliation | Systems Biology of Pain Head of the Division of Pharmacology & Toxicology Department of Pharmaceutical Sciences University of Vienna, Austria |
contact email | manuela_schmidt@univie.ac.at |
lab head | |
Christin Kappert |
contact affiliation | Max Planck Institute of Experimental Medicine |
contact email | kappert@em.mpg.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD028356
- Label: PRIDE project
- Name: Rat DRG CIPN versus Vehicle-treated mice_DIA-MS