PXD028320-2

PXD028320 is an original dataset announced via ProteomeXchange.

Title	Forward and reverse degradomics defines the proteolytic landscape of human knee osteoarthritic cartilage and the role of the serine protease HtrA1
Description	Proteolytic destruction of articular cartilage is a major pathogenic mechanism in osteoarthritis (OA), but was not previously investigated on a proteome-wide scale. We sought to define the human knee OA cartilage degradome and the contribution therein of the serine protease HtrA1, using an N-terminomics strategy, terminal amine isotopic labeling of substrates (TAILS).
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:13:40.013.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD028320
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Sumit Bhutada
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2021-09-09 08:25:09	ID requested
1	2023-11-03 09:20:08	announced
⏵ 2	2023-11-14 09:13:41	announced	2023-11-14: Updated project metadata.
3	2024-10-22 06:13:37	announced	2024-10-22: Updated project metadata.

10.6019/PXD028320;

Bhutada S, Li L, Willard B, Muschler G, Piuzzi N, Apte SS, Forward and reverse degradomics defines the proteolytic landscape of human knee osteoarthritic cartilage and the role of the serine protease HtrA1. Osteoarthritis Cartilage, 30(8):1091-1102(2022) [pubmed]

submitter keyword: Degradomics, ATOMS, Osteoarthritis, N-terminomics, HtrA1

Suneel Apte
contact affiliation	Cleveland Clinic
contact email	aptes@ccf.org
lab head
Sumit Bhutada
contact affiliation	Cleveland Clinic
contact email	bhutads@ccf.org
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/11/PXD028320

PRIDE project URI

• PRIDE
  1. PXD028320
     1. Label: PRIDE project
     2. Name: Forward and reverse degradomics defines the proteolytic landscape of human knee osteoarthritic cartilage and the role of the serine protease HtrA1