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PXD028312-2

PXD028312 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleFox serum proteomics analysis suggests host-specific responses to Angiostrongylus vasorum infection
DescriptionDogs infected with the cardiopulmonary nematode Angiostrongylus vasorum may suffer respiratory distress and/or bleeding disorders. Descriptions of clinical signs in foxes are rare, despite high prevalence. To evaluate the impact of infection on coagulation and immune response, serum proteins from eight experimentally infected foxes before and after inoculation (day 0, 35, 84, 154) were subjected to quantitative proteomic analysis and compared to available data from dogs. The number of differentially expressed proteins compared to uninfected baseline increased with chronicity of the infection. Bone marrow proteoglycan, chitinase 3-like protein 1 and pulmonary surfactant-associated protein B were among strongly upregulated proteins. Several proteins involved in coagulation were downregulated. Enriched pathways obtained from both up- and downregulated proteins included among others ‘platelet degranulation‘ and ‘haemostasis’, and indicated both activation and suppression of coagulation. Qualitative comparison to dog data suggests some parallel serum proteomic alterations. The comparison, however, highlights that foxes have a more balanced immunopathological response to A. vasorum infection compared to dogs, facilitating parasite survival in foxes. Our findings imply that foxes may cope better with an A. vasorum infection and that A. vasorum is likely more adapted to foxes as compared to dogs, explaining the relevant role of foxes as wildlife reservoir.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:30:29.077.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterNina Gillis
SpeciesList scientific name: Vulpes vulpes (Red fox); NCBI TaxID: 9627;
ModificationListacetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-09-09 08:21:20ID requested
12021-11-25 08:34:50announced
22024-10-22 05:30:29announced2024-10-22: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: proteomics,Angiostrongylus vasorum, Vulpes vulpes, immune response, coagulation, fox
Contact List
Manuela Schnyder
contact affiliationInstitute of Parasitology Vetsuisse Faculty University of Zurich Winterthurerstrasse 266a 8057 Zürich Switzerland
contact emailManuela.Schnyder@uzh.ch
lab head
Nina Gillis
contact affiliationInstitute of Parasitology, University of Zurich
contact emailnina.gillis@uzh.ch
dataset submitter
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Dataset FTP location
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