PXD028211-2
PXD028211 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomics reveals the ribosome signaling pathway promoting prostate cancer progression and correlating with poor prognosis |
Description | Through digital rectal examinations and routine prostate-specific antigen (PSA) screening, early treatment of prostate cancer has become possible. However, prostate cancer is a complex and heterogeneous disease. In many patients, cancer cells can invade adjacent tissues and metastasize to other tissues, resulting in difficultly to cure. For the treatment of primary and metastatic prostate cancer, a significant problem is how to improve its survival time. Here, we collect 7 untreated primary and metastatic prostate cancer and 6 benign prostate hyperplasia samples under ultrasound guidance by experienced radiologists using the 18-G needle. Through mass spectrometry, we have completely depicted the protein atlas of primary and metastatic prostate cancer and benign prostate hyperplasia. Through bioinformatics analysis, experimental verification, and combined clinical data, we discover that the ribosome signaling pathway promotes the progression of prostate cancer and is associated with a poor prognosis. Among them, Mrpl1, Mrpl4, and Mrpl16 may be biomolecular markers for diagnosis and prognosis. |
HostingRepository | iProX |
AnnounceDate | 2021-09-05 |
AnnouncementXML | Submission_2024-03-18_19:05:34.649.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Jiangbei Yuan |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2021-09-05 20:58:52 | ID requested | |
1 | 2023-10-31 19:05:13 | announced | |
⏵ 2 | 2024-03-18 19:05:35 | announced | 2024-03-19: Update information. |
Publication List
Fu Q, Luo L, Hong R, Zhou H, Xu X, Feng Y, Huang K, Wan Y, Li Y, Gong J, Le X, Liu X, Wang N, Yuan J, Li F, Radiogenomic analysis of ultrasound phenotypic features coupled to proteomes predicts metastatic risk in primary prostate cancer. BMC Cancer, 24(1):290(2024) [pubmed] |
Keyword List
submitter keyword: Quantitative proteomics, Ribosome signaling pathway, Prostate cancer, Mrpl16, Mrpl4, Mrpl1, Prognosis |
Contact List
Jiangbei Yuan | |
---|---|
contact affiliation | Peking University Shenzhen Hospital |
contact email | yuanjiangbei@163.com |
lab head | |
Jiangbei Yuan | |
contact affiliation | Peking University Shenzhen Hospital |
contact email | yuanjiangbei@163.com |
dataset submitter |
Full Dataset Link List
iProX dataset URI |