PXD028190-2

PXD028190 is an original dataset announced via ProteomeXchange.

Title	Long-Term Hepatitis B Virus Infection Induces Cytopathic Effects in Primary Human Hepatocytes and Can be Partially Reversed by Antiviral Therapy
Description	Global temporal quantitative proteomic and transcriptomic analysis using long-term hepatitis B virus (HBV)-infected primary human hepatocytes uncovered extensive remodeling of host proteome and transcriptome, and revealed cytopathic effects of long-term viral replication. Metabolic-, complement-, cytoskeleton-, mitochondrial- and oxidation-related pathways were modulated at transcriptional or post-transcriptional levels, which could be partially rescued by early rather than late nucleot(s)ide analogs (NAs) therapy. Overexpression screening identified a series of pro- or anti- HBV host factors. These data have deepened the understanding of the mechanisms of viral pathogenesis and HBV-host interactions in hepatocytes, with implications for therapeutic intervention.
HostingRepository	iProX
AnnounceDate	2021-08-31
AnnouncementXML	Submission_2022-10-21_02:42:00.035.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Wenjing Zai
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2021-09-01 04:56:13	ID requested
1	2021-09-01 04:56:25	announced
⏵ 2	2022-10-21 02:42:01	announced	2022-10-21: Update publication information.

Zai W, Hu K, Ye J, Ding J, Huang C, Li Y, Fang Z, Wu M, Wang C, Chen J, Yuan Z, Long-Term Hepatitis B Virus Infection Induces Cytopathic Effects in Primary Human Hepatocytes, and Can Be Partially Reversed by Antiviral Therapy. Microbiol Spectr, 10(1):e0132821(2022) [pubmed]

submitter keyword: long-term HBV infection, quantitative temporal proteomics, cytopathic effects, nucleot(s)ide analogues, viral-host interaction

Zhenghong Yuan
contact affiliation	Fudan University
contact email	zhyuan@shmu.edu.cn
lab head
Wenjing Zai
contact affiliation	Fudan University
contact email	zaiwjing@163.com
dataset submitter

iProX dataset URI