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PXD028062-1

PXD028062 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleCombined transcriptome and proteome profiling for role of pfEMP1 in antimalarial mechanism of action of dihydroartemisin
DescriptionMalaria parasites induce morphological and biochemical changes in the membranes of parasite-infected red blood cells (iRBCs) for propagation. Artemisinin combination therapies are the first-line antiplasmodials in endemic countries. However, the mechanism of action of artemisinin is unclear, and drug resistance decreases long-term efficacy. To understand whether artemisinin targets or interacts with iRBC membrane proteins, this study investigated the molecular changes caused by dihydroartemisin (DHA), an artemisinin derivative, in Plasmodium falciparum 3D7 using a combined transcriptomic and membrane proteomic profiling approach.
HostingRepositoryPRIDE
AnnounceDate2022-02-15
AnnouncementXMLSubmission_2022-02-15_07:07:10.952.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterlina chen
SpeciesList scientific name: Plasmodium falciparum 3D7; NCBI TaxID: 36329;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-08-23 06:36:34ID requested
12022-02-15 07:07:11announced
Publication List
Chen L, Zheng Z, Liu H, Wang X, Qu S, Yang Y, Deng S, Zhang Y, Tuo L, Zhao Y, Li Y, Combined Transcriptome and Proteome Profiling for Role of pfEMP1 in Antimalarial Mechanism of Action of Dihydroartemisinin. Microbiol Spectr, 9(3):e0127821(2021) [pubmed]
Keyword List
submitter keyword: malaria,dihydroartemisin, mode of action, iRBC membrane proteome
Contact List
Lina Chen
contact affiliationArtemisinin Research Center, Institute of Chinese Materia Medica, China Academy ofChinese Medical Sciences
contact emaillnchen@icmm.ac.cn
lab head
lina chen
contact affiliationChina academy of materia medica
contact emaillnchen@icmm.ac.cn
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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