PXD028062 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Combined transcriptome and proteome profiling for role of pfEMP1 in antimalarial mechanism of action of dihydroartemisin |
Description | Malaria parasites induce morphological and biochemical changes in the membranes of parasite-infected red blood cells (iRBCs) for propagation. Artemisinin combination therapies are the first-line antiplasmodials in endemic countries. However, the mechanism of action of artemisinin is unclear, and drug resistance decreases long-term efficacy. To understand whether artemisinin targets or interacts with iRBC membrane proteins, this study investigated the molecular changes caused by dihydroartemisin (DHA), an artemisinin derivative, in Plasmodium falciparum 3D7 using a combined transcriptomic and membrane proteomic profiling approach. |
HostingRepository | PRIDE |
AnnounceDate | 2022-02-15 |
AnnouncementXML | Submission_2022-02-15_07:07:10.952.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | lina chen |
SpeciesList | scientific name: Plasmodium falciparum 3D7; NCBI TaxID: 36329; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-08-23 06:36:34 | ID requested | |
⏵ 1 | 2022-02-15 07:07:11 | announced | |
Publication List
Chen L, Zheng Z, Liu H, Wang X, Qu S, Yang Y, Deng S, Zhang Y, Tuo L, Zhao Y, Li Y, Combined Transcriptome and Proteome Profiling for Role of pfEMP1 in Antimalarial Mechanism of Action of Dihydroartemisinin. Microbiol Spectr, 9(3):e0127821(2021) [pubmed] |
Keyword List
submitter keyword: malaria,dihydroartemisin, mode of action, iRBC membrane proteome |
Contact List
Lina Chen |
contact affiliation | Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy ofChinese Medical Sciences |
contact email | lnchen@icmm.ac.cn |
lab head | |
lina chen |
contact affiliation | China academy of materia medica |
contact email | lnchen@icmm.ac.cn |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD028062 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD028062
- Label: PRIDE project
- Name: Combined transcriptome and proteome profiling for role of pfEMP1 in antimalarial mechanism of action of dihydroartemisin