PXD028062-1

PXD028062 is an original dataset announced via ProteomeXchange.

Title	Combined transcriptome and proteome profiling for role of pfEMP1 in antimalarial mechanism of action of dihydroartemisin
Description	Malaria parasites induce morphological and biochemical changes in the membranes of parasite-infected red blood cells (iRBCs) for propagation. Artemisinin combination therapies are the first-line antiplasmodials in endemic countries. However, the mechanism of action of artemisinin is unclear, and drug resistance decreases long-term efficacy. To understand whether artemisinin targets or interacts with iRBC membrane proteins, this study investigated the molecular changes caused by dihydroartemisin (DHA), an artemisinin derivative, in Plasmodium falciparum 3D7 using a combined transcriptomic and membrane proteomic profiling approach.
HostingRepository	PRIDE
AnnounceDate	2022-02-15
AnnouncementXML	Submission_2022-02-15_07:07:10.952.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	lina chen
SpeciesList	scientific name: Plasmodium falciparum 3D7; NCBI TaxID: 36329;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-08-23 06:36:34	ID requested
⏵ 1	2022-02-15 07:07:11	announced

Chen L, Zheng Z, Liu H, Wang X, Qu S, Yang Y, Deng S, Zhang Y, Tuo L, Zhao Y, Li Y, Combined Transcriptome and Proteome Profiling for Role of pfEMP1 in Antimalarial Mechanism of Action of Dihydroartemisinin. Microbiol Spectr, 9(3):e0127821(2021) [pubmed]

submitter keyword: malaria,dihydroartemisin, mode of action, iRBC membrane proteome

Lina Chen
contact affiliation	Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy ofChinese Medical Sciences
contact email	lnchen@icmm.ac.cn
lab head
lina chen
contact affiliation	China academy of materia medica
contact email	lnchen@icmm.ac.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD028062

PRIDE project URI

• PRIDE
  1. PXD028062
     1. Label: PRIDE project
     2. Name: Combined transcriptome and proteome profiling for role of pfEMP1 in antimalarial mechanism of action of dihydroartemisin