PXD027893 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic study of apheresis platelets made HLA class I deficient for transfusion of refractory patients |
Description | Refractoriness can occur after repeated PLT transfusions because of alloimmunization to HLA class I antigens on transfused PLTs and generation of anti-HLA antibodies that bind to the foreign PLTs and initiate their destruction. Such refractoriness can be overcome by provision of HLA-matched PLTs from HLA typed donors. However, since the procedure is both expensive and time-consuming, an alternative approach is to deplete PLTs of HLA class I molecules by a brief treatment with citric acid, on ice at low pH. This is shown to be feasible without damaging PLT function |
HostingRepository | PRIDE |
AnnounceDate | 2022-02-14 |
AnnouncementXML | Submission_2022-02-14_01:38:52.733.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Sachin Singh |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-08-12 03:44:27 | ID requested | |
⏵ 1 | 2022-02-14 01:38:53 | announced | |
Publication List
Mirlashari MR, Vetlesen A, Nissen-Meyer LSH, Stensland ME, Singh SK, Nyman TA, Hetland G, Proteomic study of apheresis platelets made HLA class I deficient for transfusion of refractory patients. Proteomics Clin Appl, 15(6):e2100022(2021) [pubmed] |
Keyword List
submitter keyword: Platelets, HLA class I, β-2 microglobulin, Proteomics |
Contact List
Geir Hetland |
contact affiliation | Department of Immunology and Transfusion Medicine, Oslo University Hospital |
contact email | uxmoir@ous-hf.no |
lab head | |
Sachin Singh |
contact affiliation | Proteomics core facility, Olso University hospital, Norway |
contact email | sachin.kumar.singh@rr-research.no |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD027893 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD027893
- Label: PRIDE project
- Name: Proteomic study of apheresis platelets made HLA class I deficient for transfusion of refractory patients