PXD027812-1

PXD027812 is an original dataset announced via ProteomeXchange.

Title	Proteome landscape of schizophrenia in patient-derived cerebral organoids
Description	We utilized patient-derived induced pluripotent stem cells (iPSCs) to generate 3D cerebral organoids to model neuropathology of Scz during this critical period. We discovered that Scz organoids exhibited ventricular neuropathology resulting in altered progenitor survival and disrupted neurogenesis. cz organoids principally differed not in their proteomic diversity, but specifically in their total quantity of disease and neurodevelopmental factors at the molecular level. Provides unique insights into the proteome landscape of schizophrenia in patient-derived cerebral organoids
HostingRepository	PRIDE
AnnounceDate	2021-11-17
AnnouncementXML	Submission_2021-11-17_08:49:57.563.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	david greening
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2021-08-09 06:33:56	ID requested
⏵ 1	2021-11-17 08:49:57	announced

Dataset with its publication pending

submitter keyword: Proteome, schizophrenia, cerebral organoids, iPSC, neuropathology

david greening
contact affiliation	Baker Heart and Diabetes Institute
contact email	david.greening@baker.edu.au
lab head
david greening
contact affiliation	Baker Heart and Diabetes Inst.
contact email	david.greening@baker.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/11/PXD027812

PRIDE project URI

• PRIDE
  1. PXD027812
     1. Label: PRIDE project
     2. Name: Proteome landscape of schizophrenia in patient-derived cerebral organoids