PXD027718 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic Profile of Mesenchymal Stromal Cell and Extracellular Vesicle in Normoxic and Hypoxic Conditions |
| Description | The physiological niche of bone marrow is hypoxic. However, the artificial growth of bone marrow derived-mesenchymal stromal cells (MSC)s very often occurs in normoxia which may impact the protein expression with immunomodulatory properties. Thus, cell viability and respiration were assessed as well as the proteomic profile of MSCs and their EVs submitted to normoxia (21% O2) and hypoxia (1% O2) for 48 hours were evaluated. MSCs and EVs total protein were isolated for mass spectrometry. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-02-09 |
| AnnouncementXML | Submission_2026-02-08_21:40:17.136.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Pedro Silva |
| SpeciesList | scientific name: Rattus norvegicus (Rat); NCBI TaxID: NEWT:10116; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2021-08-05 05:47:34 | ID requested | |
| ⏵ 1 | 2026-02-08 21:40:18 | announced | |
Publication List
| Santos RT, Braga CL, de S, รก, Freire Onofre ME, da Silva CM, de Novaes Rocha N, Veras RG, de Souza Serra SS, Teixeira DE, Dos Santos Alves SA, Miranda BT, Pereira MG, Neves CC, de Oliveira Garcia MR, Takiya CM, Rocco PRM, Cruz FF, Silva PL, Cardioprotective effects of extracellular vesicles from hypoxia-preconditioned mesenchymal stromal cells in experimental pulmonary arterial hypertension. Stem Cell Res Ther, 16(1):466(2025) [pubmed] |
| 10.1186/s13287-025-04604-y; |
Keyword List
| submitter keyword: Proteomic, Cell Respiration, Cell Viability,Bone Marrow derived-Mesenchymal Stromal Cells, Hypoxia |
Contact List
| Pedro Leme Silva |
|---|
| contact affiliation | Laboratory of Pulmonary Investigation, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro |
| contact email | pedroleme@biof.ufrj.br |
| lab head | |
| Pedro Silva |
|---|
| contact affiliation | Federal University of Rio de Janeiro |
| contact email | pedroleme@biof.ufrj.br |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD027718 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD027718
- Label: PRIDE project
- Name: Proteomic Profile of Mesenchymal Stromal Cell and Extracellular Vesicle in Normoxic and Hypoxic Conditions
