PXD027601-1

PXD027601 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	The effect of TCOF1 on renal cancer proteome
Description	TCOF1 encodes treacle, a multifunctional protein involved in ribosome biogenesis, regulation of mitosis, proliferation, response to DNA damage, and apoptosis. TCOF1 mutations cause Treacher Collins syndrome, a rare genetic disorder leading to craniofacial malformations. The expression of TCOF1 is disturbed in renal cancer. The global effects of TCOF1 dysfunction in cancer are unknown. Here, we explored the effect of TCOF1 depletion on proteome of renal cancer.
HostingRepository	PRIDE
AnnounceDate	2026-05-25
AnnouncementXML	Submission_2026-05-24_17:09:39.840.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jacek Wisniewski
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: NEWT:10116;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2021-07-27 07:39:33	ID requested
⏵ 1	2026-05-24 17:09:40	announced

Publication List

Grzanka M, Pop, ł, awski P, Wi, ś, niewski JR, Iwanicka-Nowicka R, Kossowska H, Koblowska M, Rybicka B, Bia, ł, as A, Piekie, ł, ko-Witkowska A, TCOF1 affects Golgi secretory pathway contributing to the angiogenesis in renal cancer. Cell Commun Signal, 24(1):(2026) [pubmed]
10.1186/s12964-026-02796-1;

Grzanka M, Pop, ł, awski P, Wi, ś, niewski JR, Iwanicka-Nowicka R, Kossowska H, Koblowska M, Rybicka B, Bia, ł, as A, Piekie, ł, ko-Witkowska A, TCOF1 affects Golgi secretory pathway contributing to the angiogenesis in renal cancer. Cell Commun Signal, 24(1):(2026) [pubmed]

10.1186/s12964-026-02796-1;

Keyword List

submitter keyword: TCOF1, renal cancer, treacle

submitter keyword: TCOF1, renal cancer, treacle

Contact List

Jacek R Wisniewski
contact affiliation	Max Planck Institute of Biochemistry. Martinsried, Germany
contact email	jwisniew@biochem.mpg.de
lab head
Jacek Wisniewski
contact affiliation	Proteomics
contact email	jwisniew@biochem.mpg.de
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD027601
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD027601

PRIDE project URI

Repository Record List

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