PXD027462-2
PXD027462 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | OGT-mediated AIMP2 O-GlcNAcylation promotes PARP1 overactivation in ageing-associated liver steatosis |
Description | We identified 245 down-regulated and 343 up-regulated liver proteins in aged mice. Of note, the proteins Xbp1 and Bax, which are well recognized to be involved in the regulation of ageing, were also enriched, indicating that our proteomics results are credible. Moreover,some of enriched proteins are involved in cellular processes that are widely recognized as important for aging. Livers of ageing mice exhibited changed methylation, loss of proteostasis (protein folding alteration, decreased autophagy, and increased ubiquitination), increased apoptosis, dysregulated rhythmic process, and gut dysbiosis. |
HostingRepository | jPOST |
AnnounceDate | 2022-07-21 |
AnnouncementXML | Submission_2022-09-18_03:06:52.278.xml |
DigitalObjectIdentifier | |
ReviewLevel | Non peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Renlong Li |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | L-methionine sulfoxide |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2021-07-21 02:25:59 | ID requested | |
1 | 2022-07-20 08:00:06 | announced | |
⏵ 2 | 2022-09-18 03:06:52 | announced | 2022-09-18: Updated FTP location. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: ageing-associated NAFLD, proteomics, AIMP2,PARP1, OGT, O-GlcNAcylation |
Contact List
Yongzhan Nie | |
---|---|
lab head | |
Renlong Li | |
contact affiliation | Xijing Digestive Proteomics Core, Four Military Medical University, China |
dataset submitter |
Full Dataset Link List
jPOST dataset URI |
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST001196/ |