PXD027278 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Candida albicans CUG codon translation, comparison with other yeasts |
Description | Candida yeasts causing human infections are spread across the yeast phylum with Candida glabrata being related to Saccharomyces cerevisiae, Candida krusei grouping to Pichia spp., and Candida albicans, Candida parapsilosis and Candida tropicalis belonging to the CTG-clade. The latter lineage contains yeasts with an altered genetic code translating CUG codons as serine using a serine-tRNA with a mutated anticodon. It has been suggested that the CTG-clade CUG codons are mistranslated to a small extent as leucine due to mischarging of the serine-tRNA(CAG). The mistranslation was suggested to result in variable surface proteins explaining fast host adaptation and pathogenicity. Here, we re-assessed this potential mistranslation by high-resolution mass spectrometry-based proteogenomics of multiple CTG-clade yeasts, various C. albicans strains, isolated from colonized and from infected human body sites, and C. albicans grown in yeast and hyphal forms. |
HostingRepository | PRIDE |
AnnounceDate | 2021-11-17 |
AnnouncementXML | Submission_2021-11-17_10:26:16.916.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Martin Kollmar |
SpeciesList | scientific name: Candida albicans (Yeast); NCBI TaxID: 5476; scientific name: Candida dubliniensis CD36; NCBI TaxID: 573826; scientific name: Millerozyma acaciae; NCBI TaxID: 28986; scientific name: Candida albicans SC5314; NCBI TaxID: 237561; scientific name: Candida tropicalis; NCBI TaxID: 5482; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive; Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-07-13 21:58:47 | ID requested | |
⏵ 1 | 2021-11-17 10:26:17 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Candida albicans, Candida dubliniensis, Candida tropicalis, |
Contact List
Martin Kollmar |
contact affiliation | Group Systems Biology of Motor Proteins, Department of NMR-based Structural Biology, Max-Planck-Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany |
contact email | mako@nmr.mpibpc.mpg.de |
lab head | |
Martin Kollmar |
contact affiliation | MPI for Biophysical Chemistry |
contact email | mako@nmr.mpibpc.mpg.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD027278
- Label: PRIDE project
- Name: Candida albicans CUG codon translation, comparison with other yeasts