PXD027186-1

PXD027186 is an original dataset announced via ProteomeXchange.

Title	GFP-DLC1 interactome in MCF7 breast cancer cells
Description	The Rho GTPase activating protein Deleted in Liver Cancer 1 (DLC1) is frequently downregulated through genetic and epigenetic mechanisms in various malignancies, leading to aberrant Rho GTPase signaling and thus facilitating cancer progression. The aim of this project was to identify novel interaction partners, that could be involved in the regulation of DLC1 proteasomal degradation.
HostingRepository	PRIDE
AnnounceDate	2022-05-20
AnnouncementXML	Submission_2022-05-20_02:11:32.277.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Nicolas Nalpas
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	methylated residue; phosphorylated residue; acetylated residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2021-07-08 04:20:11	ID requested
⏵ 1	2022-05-20 02:11:33	announced

Frey Y, Franz-Wachtel M, Macek B, Olayioye MA, Proteasomal turnover of the RhoGAP tumor suppressor DLC1 is regulated by HECTD1 and USP7. Sci Rep, 12(1):5036(2022) [pubmed]

submitter keyword: RhoGAP, DLC1, breast cancer, MCF7

Monilola Olayioye
contact affiliation	University of Stuttgart, Germany, Institute of Cell Biology and Immunology
contact email	monilola.olayioye@izi.uni-stuttgart.de
lab head
Nicolas Nalpas
contact affiliation	Tuebingen University
contact email	nalpas.nicolas@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/05/PXD027186

PRIDE project URI

• PRIDE
  1. PXD027186
     1. Label: PRIDE project
     2. Name: GFP-DLC1 interactome in MCF7 breast cancer cells