PXD027111 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | The plasma proteins from human multiple myeloma was enriched by lectin AANL6 and identified by LC-MS/MS |
Description | Lectin is widely used to enrich glycoconjugates carrying glycans and to identify the abnormal glycosylated proteins in tumor with mass spectrometry, which is a useful tool for cancer diagnosis and prognosis monitoring. In our previously reported, we identified a novel lectin AANL from Agrocybe aegerita that has a higher affinity than other lectins when binding with GlcNAc, and the lectin AANL has been used for early diagnosis of non-small cell lung cancer. Subsequently, AANL6, a mutant of AANL, is cloned and purified, and has higher affinity to terminal GlcNAc than AANL. Therefore, in this study, we used the lectin AANL6 for enrichment of glycosylated peoteins from MM, and identified with quantitative proteomics, in order to find a potential sensitive biomarker for MM diagnosis. |
HostingRepository | PRIDE |
AnnounceDate | 2024-05-22 |
AnnouncementXML | Submission_2024-05-22_01:48:22.337.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Yanxia Jin |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monomethylated residue |
Instrument | TripleTOF 5600 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-07-05 08:55:53 | ID requested | |
⏵ 1 | 2024-05-22 01:48:23 | announced | |
Publication List
Jin Y, Liang Y, Su Y, Hui L, Liu H, Ding L, Zhou F, Identification of novel combined biomarkers in the diagnosis of multiple myeloma. Hematology, 26(1):964-969(2021) [pubmed] |
10.1080/16078454.2021.2003065; |
Keyword List
submitter keyword: Lectin AANL6, MM, Human, Plasma, LC-MS/MS |
Contact List
Yanxia Jin |
contact affiliation | Wuhan University |
contact email | jinyanxia@hbnu.edu.cn |
lab head | |
Yanxia Jin |
contact affiliation | Hubei Normal University |
contact email | jinyanxia@hbnu.edu.cn |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD027111
- Label: PRIDE project
- Name: The plasma proteins from human multiple myeloma was enriched by lectin AANL6 and identified by LC-MS/MS