PXD026978-1

PXD026978 is an original dataset announced via ProteomeXchange.

Title	Sex-specific social behavior and amygdala proteomic deficits in Foxp2+/- mutant mice
Description	In humans, mutations in the transcription factor encoding gene, FOXP2, are associated with language and Autism Spectrum (ASD) Disorders, the latter characterized by deficits in social interactions. However, little is known regarding the function of Foxp2 in male or female social behavior. Our previous studies in mice revealed high expression of Foxp2 within the medial subnucleus of the amygdala (MeA), a limbic brain region highly implicated in innate social behaviors such as mating, aggression, and parental care. Here, using a comprehensive panel of behavioral tests in male and female Foxp2+/- heterozygous mice, we investigated the role Foxp2 plays in MeA-linked innate social behaviors. We reveal significant deficits in olfactory processing, social interaction, mating, aggressive and parental behaviors. Interestingly, some of these deficits displayed in a sex-specific manner. To examine the consequences of Foxp2 loss of function specifically in the MeA, we conducted a proteomic analysis of microdissected MeA tissue and found sex differences in a host of proteins implicated in neuronal communication, connectivity and dopamine signaling. Consistent with this, we discovered that MeA Foxp2-lineage cells were responsive to dopamine with differences between males and females. Thus, our findings reveal a central and sex-specific role for Foxp2 in social behavior and MeA function.
HostingRepository	PRIDE
AnnounceDate	2021-07-07
AnnouncementXML	Submission_2021-07-06_23:40:49.634.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Maria Jesus Herrero
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-06-28 21:20:03	ID requested
⏵ 1	2021-07-06 23:40:50	announced

Dataset with its publication pending

submitter keyword: Foxp2, medial amygdala (MeA), social behavior, aggression, sex-specific differences, proteomics

Joshua Corbin
contact affiliation	Center for Neuroscience Research, Children's National Hospital, Washington, DC. 20010 USA
contact email	JCorbin@childrensnational.org
lab head
Maria Jesus Herrero
contact affiliation	Children's National Medical Center
contact email	mjhr@um.es
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD026978
     1. Label: PRIDE project
     2. Name: Sex-specific social behavior and amygdala proteomic deficits in Foxp2+/- mutant mice