PXD026962-1
PXD026962 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Multi-omic Profiling of Plasma Identify Biomarkers and Pathogenesis of COVID-19 in Children |
| Description | Although people of all ages are susceptible to COVID-19, children usually develop less severe disease than adults. Little is known about the pathogenesis of COVID-19 in children. Herein, we conduct the plasma proteomic and metabolomic profiling of a cohort of COVID-19 children patients with mild symptoms, and uncovered that many proteins involved in immune response are significantly up-regulated in a stronger extent than in adults with COVID-19. Interestingly, more molecules involved in protective processes of reducing inflammation are also stimulated to antagonize the deleterious effect in both proteomic and metabolomic levels. By developing a machine learning-based pipeline, we prioritize two set of biomarker combinations, and identify 5 proteins and 5 metabolites as potentially children-specific biomarkers. Further experiments demonstrate these protective metabolites not only inhibit the expression of pro-inflammatory factors, but also suppress the viral replication. Taken together, our study not only discover the protective mechanisms in children with COVID-19, but also shed light on potential therapies targets for treating COVID-19. |
| HostingRepository | iProX |
| AnnounceDate | 2021-06-28 |
| AnnouncementXML | Submission_2021-06-28_01:26:39.414.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yang Qiu |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | QTRAP 6500+ |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2021-06-28 01:26:02 | ID requested | |
| ⏵ 1 | 2021-06-28 01:26:39 | announced | |
| 2 | 2023-02-20 22:59:58 | announced | 2023-02-21: Update information. |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Multi-omic Profilingļ¼COVID-19ļ¼Children |
Contact List
| Xi Zhou | |
|---|---|
| contact affiliation | Wuhan Institue of Virology, CAS |
| contact email | zhouxi@wh.iov.cn |
| lab head | |
| Yang Qiu | |
| contact affiliation | Wuhan Institue of Virology, CAS |
| contact email | yangqiu@wh.iov.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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