PXD026861-2

PXD026861 is an original dataset announced via ProteomeXchange.

Title	LPA-TriCEPS crosslinked to human VICs
Description	We used ligand-receptor capture mass spectrometry that identified major facilitator superfamily domain containing 5 (MFSD5) as a previously unreported Lp(a) receptor.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:18:50.808.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sasha Singh
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2021-06-22 02:57:08	ID requested
1	2023-12-27 12:59:09	announced
⏵ 2	2024-10-22 06:18:58	announced	2024-10-22: Updated project metadata.

10.1161/circulationaha.123.066822;

Rogers MA, Bartoli-Leonard F, Zheng KH, Small AM, Chen HY, Clift CL, Asano T, Kuraoka S, Blaser MC, Perez KA, Natarajan P, Yeang C, Stroes ESG, Tsimikas S, Engert JC, Thanassoulis G, O'Donnell CJ, Aikawa M, Singh SA, Aikawa E, Major Facilitator Superfamily Domain Containing 5 Inhibition Reduces Lipoprotein(a) Uptake and Calcification in Valvular Heart Disease. Circulation, 149(5):391-401(2024) [pubmed]

submitter keyword: MFSD5, mass spectrometry, valve interstitial cells

Elena Aikawa
contact affiliation	Brigham and Women's Hospital and Harvard Medical School
contact email	eaikawa@bwh.harvard.edu
lab head
Sasha Singh
contact affiliation	Brigham and Women's Hospital, Harvard Medical School
contact email	sasingh@bwh.harvard.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/12/PXD026861

PRIDE project URI

• PRIDE
  1. PXD026861
     1. Label: PRIDE project
     2. Name: LPA-TriCEPS crosslinked to human VICs