PXD026849-1

PXD026849 is an original dataset announced via ProteomeXchange.

Title	Targeted validation of significantly altered semen proteins in COVID-19 patients
Description	The current global outbreak of COVID-19 has significantly impacted several organ systems. Male reproductive organs are among the potential targets of SARS-CoV-2 infection owing to the presence of abundant viral receptors; ACE2 and TMPRSS2 in the testis. However, the questions pertaining to the long term effects of SARS-CoV-2 infection on male fertility are still unanswered. For this study, we procured the semen samples from COVID-19 recovered patients and performed mass spectrometry based proteomic studies to understand the impact of the disease on the biological processes involved in reproductive health.
HostingRepository	PanoramaPublic
AnnounceDate	2022-06-26
AnnouncementXML	Submission_2022-06-26_22:59:03.458.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Sanjeeva Srivastava
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	Carbamidomethyl; Label:13C(6)15N(2)
Instrument	TSQ Altis

Revision	Datetime	Status	ChangeLog Entry
0	2021-06-21 19:57:05	ID requested
⏵ 1	2022-06-26 22:59:04	announced

Ghosh S, Parikh S, Nissa MU, Acharjee A, Singh A, Patwa D, Makwana P, Athalye A, Barpanda A, Laloraya M, Srivastava S, Parikh F, Semen Proteomics of COVID-19 Convalescent Men Reveals Disruption of Key Biological Pathways Relevant to Male Reproductive Function. ACS Omega, 7(10):8601-8612(2022) [pubmed]

submitter keyword: SARS-CoV-2, COVID-19, SRM/MRM, Proteomics, Semen

Sanjeeva Srivastava
contact affiliation	Biosciences and Bioengineering Department, IIT Bombay
contact email	sanjeeva@iitb.ac.in
lab head
Sanjeeva Srivastava
contact affiliation	Biosciences and Bioengineering Department, IIT Bombay
contact email	sanjeeva@iitb.ac.in
dataset submitter

Panorama Public dataset URI