PXD026784 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Biochemical network analysis of protein-protein interactions to monitor the course of T1 bladder cancer patients |
| Description | Mass spectrometry-based personalized medicine was used to uncover key information in T1-stage bladder cancer (BC) patients and used as a tool to aid clinical decision making. The urinary proteome of patients with recurring versus non-recurring T1-stage BC were compared to uncover information for clinical decision making. Our results suggest the urinary myeloperoxidase to cubilin ratio as a new tool to address recurrence as well as dysregulation of the inflammatory and immune systems as drivers of a worsening disease course. Furthermore, dysregulation of neutrophil extracellular traps (NETs) is pinpointed as the leading way by which malignancy progress in BC showing the formation of an inflammatory microenvironment that facilitates immune cell-matrix cross-talk and promotes a state of chronic inflammation. We conclude that inflammation dysregulation is an important driver of BC recurrence and progression, and that anti-inflammatory or immune checkpoint therapies should be further explored in the treatment of patients with BC. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-11-11 |
| AnnouncementXML | Submission_2025-11-11_01:29:38.322.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Hugo M. Santos |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | impact HD |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2021-06-18 03:50:29 | ID requested | |
| ⏵ 1 | 2025-11-11 01:29:38 | announced | |
Publication List
Keyword List
| submitter keyword: myeloperoxidase (MPO) |
| cubilin (CUBN).,Bladder cancer |
| urine |
| proteomics |
| label-free quantification |
| mass spectrometry |
| tumor associated neutrophile, neutrophil extracellular traps |
Contact List
| Hugo M. Santos |
|---|
| contact affiliation | NOVA School of Science and Technology, NOVA University of Lisbon (lab head) |
| contact email | hmsantos@fct.unl.pt |
| lab head | |
| Hugo M. Santos |
|---|
| contact affiliation | LAQV-REQUIMTE, Department of Chemistry, School of Science and Technology, NOVA University of Lisbon |
| contact email | hmsantos@fct.unl.pt |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD026784 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD026784
- Label: PRIDE project
- Name: Biochemical network analysis of protein-protein interactions to monitor the course of T1 bladder cancer patients
