PXD026732-1

PXD026732 is an original dataset announced via ProteomeXchange.

Title	Effects of dietary protein from different sources on biotransformation, antioxidation, inflammation and exerted a great impact on lipid metabolism and mitochondrial oxidative phosphorylation in the rat liver
Description	In this work, the effects of different sources of meat protein on liver metabolic enzymes were investigated. Rats were fed for 90 days with semisynthetic diets in which casein was fully replaced by isolated soybean, fish, chicken, pork, or beef proteins. Then, liver proteomics was performed using iTRAQ and LC−ESI−MS/MS. The results indicated that intake of meat protein diets significantly reduced the protein levels of CYP450s, GSTs, UGTs, and SULTs compared to those of the casein and soybean protein diet groups. The total antioxidant capacity and lipid peroxidation values did not differ between four meat protein diet groups and the casein diet group. However, GSH activity in the fish, chicken, and beef protein groups was significantly higher than those of the casein and soybean protein groups. The beef protein diet significantly upregulated the expression of immune-related proteins. The Keap1-Nrf2-ARE signaling pathway was suggested to involve the diet-mediated regulation of biotransformation, inflammation, and redox status.
HostingRepository	PRIDE
AnnounceDate	2022-02-17
AnnouncementXML	Submission_2022-02-17_04:38:12.598.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zixin Huang
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	iTRAQ8plex-116 reporter+balance reagent acylated residue
Instrument	Thermo Fisher Scientific instrument model

Revision	Datetime	Status	ChangeLog Entry
0	2021-06-15 15:44:11	ID requested
⏵ 1	2022-02-17 04:38:17	announced
2	2024-02-12 09:03:47	announced	2024-02-12: Updated project metadata.

Shi X, Huang Z, Zhou G, Li C, Dietary Protein From Different Sources Exerted a Great Impact on Lipid Metabolism and Mitochondrial Oxidative Phosphorylation in Rat Liver. Front Nutr, 8():719144(2021) [pubmed]

submitter keyword: dietary protein, rat liver, proteomics,biotransformation, inflammation

Chunbao Li
contact affiliation	College of Food Science and Technology, Nanjing Agricultural University, Nanjing, China
contact email	chunbao.li@njau.edu.cn
lab head
Zixin Huang
contact affiliation	570141984@qq.com
contact email	2020208013@stu.njau.edu.cn
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD026732
     1. Label: PRIDE project
     2. Name: Effects of dietary protein from different sources on biotransformation, antioxidation, inflammation and exerted a great impact on lipid metabolism and mitochondrial oxidative phosphorylation in the rat liver