PXD026731-1

PXD026731 is an original dataset announced via ProteomeXchange.

Title	Diverse mitochondrial abnormalities in a new cellular model of TAFFAZZIN deficiency are remediated by Cardiolipin-interacting small molecules
Description	With the goal of identifying unappreciated pathways of mitochondrial dysregulation in Barth Syndrome, we utilized an unbiased proteomics strategy to identify pathways of metabolic dysregulation in an HEK293-based TAZ-deficiency model.
HostingRepository	PRIDE
AnnounceDate	2022-02-17
AnnouncementXML	Submission_2022-02-17_04:40:08.511.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD026731
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Hilary Vernon
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; iodoacetamide derivatized residue; deamidated residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2021-06-15 15:43:41	ID requested
⏵ 1	2022-02-17 04:40:09	announced

Anzmann AF, Sniezek OL, Pado A, Busa V, Vaz FM, Kreimer SD, DeVine LR, Cole RN, Le A, Kirsch BJ, Claypool SM, Vernon HJ, Diverse mitochondrial abnormalities in a new cellular model of TAFFAZZIN deficiency are remediated by cardiolipin-interacting small molecules. J Biol Chem, 297(3):101005(2021) [pubmed]

submitter keyword: Cardiolipin, Barth Syndrome

Hillary Vernon
contact affiliation	Department of Medical Genetics Johns Hopkins School of Medicine
contact email	hvernon1@jhmi.edu
lab head
Hilary Vernon
contact affiliation	Johns Hopkins University School of Medicine
contact email	hvernon1@jhmi.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD026731
     1. Label: PRIDE project
     2. Name: Diverse mitochondrial abnormalities in a new cellular model of TAFFAZZIN deficiency are remediated by Cardiolipin-interacting small molecules