PXD026680-2

PXD026680 is an original dataset announced via ProteomeXchange.

Title	Proteomic and Metabolomic Profiling of Acute and Chronic Stress Events Associated with Military Exercises
Description	By characterizing physiological changes that occur in warfighters during simulated combat, we can start to unravel the key biomolecular components that are linked to physical and cognitive performance and fatigue. Viable field-based sensors for the warfighter must be rapid and noninvasive. In an effort to facilitate this, we applied a multiomics pipeline to characterize the stress response in the saliva of warfighters to correlate biomolecular changes with overall performance and health. In this study, two different stress models were observed – one of chronic stress and one of acute stress. In both models, significant perturbations in the immune, metabolic, and protein manufacturing/processing systems were observed. However, when differentiating between the two stress models, specific metabolites associated with “fight or flight” response and protein folding were seen to be discriminate of the acute stress model.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:52:57.252.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Justin McKetney
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2021-06-14 05:34:54	ID requested
1	2022-07-25 23:14:04	announced
⏵ 2	2023-11-14 08:52:57	announced	2023-11-14: Updated project metadata.

Dataset with its publication pending

submitter keyword: Human Saliva Stress

Joshua J Coon
contact affiliation	Professor, Biomolecular Chemistry, University of Wisconsin - Madison
contact email	jcoon@chem.wisc.edu
lab head
Justin McKetney
contact affiliation	University of California-San Francisco
contact email	mcketney@wisc.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/07/PXD026680

PRIDE project URI

• PRIDE
  1. PXD026680
     1. Label: PRIDE project
     2. Name: Proteomic and Metabolomic Profiling of Acute and Chronic Stress Events Associated with Military Exercises