PXD026645 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Targeting DDR1 and DDR2 overcomes matrix-mediated melanoma cell adaptation to BRAF-targeted therapy |
| Description | To investigate the contribution of fibroblast-derived extracellular matrices (ECMs) to the resistance to targeted therapies in BRAF-mutated melanoma cells, we generated native-like 3D ECMs from human primary fibroblasts obtained from healthy individuals or melanoma patients. Cell-derived matrices from human dermal fibroblasts (HDF), skin melanoma associated fibroblasts (MAF) and two different lymph node fibroblast reticular cells (FRC) were denuded of cells and their composition was analyzed by mass spectrometry. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-01-30 |
| AnnouncementXML | Submission_2026-01-30_00:47:39.882.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | AUDEBERT Stephane |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue |
| Instrument | Q Exactive Plus |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2021-06-11 06:23:41 | ID requested | |
| 1 | 2021-11-11 23:50:05 | announced | |
| ⏵ 2 | 2026-01-30 00:47:40 | announced | 2026-01-30: Updated project metadata. |
Publication List
| 10.15252/emmm.201911814; |
| Berestjuk I, Lecacheur M, Carminati A, Diazzi S, Rovera C, Prod'homme V, Ohanna M, Popovic A, Mallavialle A, Larbret F, Pisano S, Audebert S, Passeron T, Gaggioli C, Girard CA, Deckert M, Tartare-Deckert S, Targeting Discoidin Domain Receptors DDR1 and DDR2 overcomes matrix-mediated tumor cell adaptation and tolerance to BRAF-targeted therapy in melanoma. EMBO Mol Med, 14(2):e11814(2022) [pubmed] |
Keyword List
| submitter keyword: LC-MSMS, resistance, targeted therapies,melanoma, DDR, extracellular matrix |
Contact List
| Deckert Marcel |
|---|
| contact affiliation | C3M – Inserm U1065 Centre Méditerranéen de Médecine Moléculaire Team: Microenvironment, signaling and cancer Bâtiment Universitaire ARCHIMED 151 route Saint Antoine de Ginestière BP 2 3194 06204 NICE CEDEX 3 |
| contact email | Marcel.DECKERT@unice.fr |
| lab head | |
| AUDEBERT Stephane |
|---|
| contact affiliation | Marseille Proteomic, Centre de Recherche en Cancérologie de Marseille, Inserm UMR1068, CNRS UMR7258, Aix Marseille Université U105, Institut Paoli Calmettes, 27 Boulevard Leï Roure CS30059 13273 Marseille Cedex 09 France |
| contact email | stephane.audebert@inserm.fr |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/11/PXD026645 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD026645
- Label: PRIDE project
- Name: Targeting DDR1 and DDR2 overcomes matrix-mediated melanoma cell adaptation to BRAF-targeted therapy
