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PXD026593-2
PXD026593 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic signatures of schizophrenia-sourced iPSC-derived neural progenitors and neurons |
| Description | Schizophrenia is a complex and severe neuropsychiatric disorder, with a wide range of debilitating symptoms. Several aspects of its multifactorial complexity are still unknown, and some are accepted to be an early developmental deficiency with a more specifically neurodevelopmental origin. Understanding timepoints of disturbances during neural cell differentiation processes could lead to an insight into the development of the disorder. In this context, human brain organoids and neural cells differentiated from patient-derived induced pluripotent stem cells are of great interest as a model to study the developmental origins of the disease. Here we evaluated the differential expression of proteins of schizophrenia patient-derived neural progenitors, early neurons, and brain organoids. Using bottom-up shotgun proteomics with a label-free approach for quantitative analysis. Multiple dysregulated proteins were found in pathways related to synapses, in line with postmortem tissue studies of schizophrenia patients. However, organoids and immature neurons exhibit impairments in pathways never before found in patient-derived induced pluripotent stem cell studies, such as spliceosomes and amino acid metabolism. In conclusion, here we provide comprehensive, large-scale, protein-level data that may uncover underlying mechanisms of the developmental origins of schizophrenia. |
| HostingRepository | PRIDE |
| AnnounceDate | 2023-11-14 |
| AnnouncementXML | Submission_2023-11-14_08:44:09.650.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Juliana Minardi Nascimento |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | Synapt MS |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2021-06-09 04:17:03 | ID requested | |
| 1 | 2023-03-11 14:40:41 | announced | |
| ⏵ 2 | 2023-11-14 08:44:10 | announced | 2023-11-14: Updated project metadata. |
| 3 | 2024-10-22 05:43:51 | announced | 2024-10-22: Updated project metadata. |
Publication List
Keyword List
| submitter keyword: neuron, SCZ,neural cell, disease, hNPC, organoid, iPS, proteome |
Contact List
| Daniel Martins-de-Souza | |
|---|---|
| contact affiliation | Lab of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil |
| contact email | dmsouza@unicamp.br |
| lab head | |
| Juliana Minardi Nascimento | |
| contact affiliation | University of Campinas |
| contact email | juminardi@gmail.com |
| dataset submitter | |
Full Dataset Link List
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD026593 |
| PRIDE project URI |
Repository Record List
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