<<< Full experiment listing

PXD026539-1

PXD026539 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleCDK4/6 inhibition promotes anti-tumor immunity
DescriptionPharmacologicalinhibitors of cyclin dependent kinases 4 and 6 (CDK4/6) are an approvedtreatment forhormone receptor-positive breast cancer and are currently under evaluation across hundreds of clinical trials for other cancertypes. The clinical success of these inhibitorsis largely attributedto well-defined tumor-intrinsic cytostatic mechanisms, while their emerging role as immunomodulatory agents is lessunderstood. Usingintegrated epigenomic, transcriptomic and proteomicanalyses, we demonstrateda novel action of CDK4/6inhibitorsin promoting the phenotypic and functional acquisition of immunological T cell memory.Short-term priming with a CDK4/6inhibitorpromoted long-termendogenousanti-tumor T cell immunityin mice, enhanced the persistence and therapeutic efficacy of chimeric antigen receptor (CAR)-T cells, and induced an RB-dependent T cell phenotype supportive offavorable responses to immune checkpoint blockade in melanoma patients.Together, thesemechanistic insights significantlybroaden the prospective utility of CDK4/6 inhibitors as clinical tools to boostanti-tumorT cell immunity.
HostingRepositoryPRIDE
AnnounceDate2021-06-08
AnnouncementXMLSubmission_2021-06-07_22:34:45.854.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJarrod Sandow
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListphosphorylated residue
InstrumenttimsTOF Pro
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-06-07 06:07:38ID requested
12021-06-07 22:34:46announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: CDK4, t-cell, phosphoproteomics, CDK6
Contact List
Stephin J. Vervoort
contact affiliationPeter MacCallum Cancer Centre, 305 Grattan St Melbourne VIC 3000
contact emailstephin.vervoort@petermac.org
lab head
Jarrod Sandow
contact affiliationWEHI
contact emailsandow@wehi.edu.au
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/06/PXD026539
PRIDE project URI
Repository Record List
[ + ]