PXD026529 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Spatial multiomics identifies CNS drug targets for progressive multiple sclerosis |
Description | Progressive multiple sclerosis (MS) is driven by persistent neuronal injury, causes cumulative disability and is refractory to current treatments. Drug development to prevent disease progression is an urgent and unmet clinical need, yet is constrained by an incomplete understanding of its complex pathogenesis. Here, we performed spatial transcriptomics and proteomics of progressive MS brain tissue to delineate this complexity and to translate our findings into therapeutic targets aimed at rescuing dying neurons. We discovered micro-areas of structurally intact cortex, which exhibited reduced neuronal pro-survival signals within an imbalanced pro- and anti-inflammatory milieu, unmasking new therapeutic possibilities to prevent further decline. Spatially resolved ligand–receptor interactome analysis identified targetable intercellular interactions including G-protein coupled receptor GRP37L1 and growth factor receptors, such as FGFR3, which are central to the survival of CNS cells, in prticular neurons. These findings place progressive MS in a new light and provide promising opportunities to overcome neurodegeneration. |
HostingRepository | PRIDE |
AnnounceDate | 2022-06-06 |
AnnouncementXML | Submission_2022-06-05_20:38:43.995.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Fabian Coscia |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF-X |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-06-07 02:46:42 | ID requested | |
⏵ 1 | 2022-06-05 20:38:44 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Multiple Sclerosis Spatial Proteomics |
Contact List
Lars Fugger |
contact affiliation | University of Oxford |
contact email | lars.fugger@ndcn.ox.ac.uk |
lab head | |
Fabian Coscia |
contact affiliation | University of Copenhagen NNF Center for Protein Research |
contact email | fabian.coscia@cpr.ku.dk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/06/PXD026529 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD026529
- Label: PRIDE project
- Name: Spatial multiomics identifies CNS drug targets for progressive multiple sclerosis