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PXD026411-1

PXD026411 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleQuantitative proteome for C.elegans by 3plex mTRAQ
DescriptionVesicle-mediated transport is a fundamental part of the secretory and endocytic pathways. In addition to their role in membrane protein trafficking, Arf-like protein subfamily of small GTPases also plays an important role in development, maintenance of Golgi structure and function. Proper protein trafficking is critical for cellular integrity and studies demonstrate that aberrant protein sorting leads to various diseases in many organisms including humans. However, to date, there is no report showing the role of Golgi apparatus and Golgi proteins in organismal longevity. Organisms dynamically reprogram their transcriptome and proteome as a response to internal and external changes, which alter physiological processes including aging. Compared to many transcriptomic studies that identified aging-regulatory genes, proteomic studies that identified aging-regulatory proteins are relatively scarce. By using a quantitative proteomic approach, we identified MON-2, an Arf-Gef protein implicated in Golgi-to-endosome trafficking, as a longevity-promoting protein. We found that MON-2 is essential for the long lifespan of various longevity mutants. Our results demonstrate that Golgi-to-endosome trafficking is an integral part of lifespan regulation.
HostingRepositoryPRIDE
AnnounceDate2022-02-17
AnnouncementXMLSubmission_2022-02-17_04:26:49.003.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterShinyeong Ju
SpeciesList scientific name: Caenorhabditis elegans; NCBI TaxID: 6239;
ModificationListNo PTMs are included in the dataset
InstrumentLTQ Orbitrap
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-06-01 22:08:26ID requested
12022-02-17 04:26:49announced
Publication List
Jung Y, Artan M, Kim N, Yeom J, Hwang AB, Jeong DE, Altintas Ö, Seo K, Seo M, Lee D, Hwang W, Lee Y, Sohn J, Kim EJE, Ju S, Han SK, Nam HJ, Adams L, Ryu Y, Moon DJ, Kang C, Yoo JY, Park SK, Ha CM, Hansen M, Kim S, Lee C, Park SY, Lee SV, . Sci Adv, 7(49):eabj8156(2021) [pubmed]
Keyword List
submitter keyword: C. elegans, mTRAQ, LC-MS/MS
Contact List
Cheolju Lee
contact affiliationCenter for Theragnosis, Korea Institute of Science and Technology, Republic of Korea
contact emailclee270@kist.re.kr
lab head
Shinyeong Ju
contact affiliationKIST
contact emailsyju@kist.re.kr
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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