PXD026335-1

PXD026335 is an original dataset announced via ProteomeXchange.

Title	Mouse Heart SS-31 Proteome and Phosphoproteome
Description	The heart proteome and phosphoproteome were analyzed in young (5-6-month old), old (24-month old at the start of the study), and elamipretide-treated (for 8 weeks) old mice using shotgun proteomics methods in order to assess the effects of aging on signaling and the ability of mitochondrion-targeted drug elamipretide (SS-31) to reverse age-related changes. Enhancement and suppression of phosphorylation at sites along a variety of proteins was found to occur with age. Elamipretide treatment partially restored the phosphorylation state of proteins that had increased phosphorylation with age, but did not have a large effect those that had decreased phosphorylation with age.
HostingRepository	PRIDE
AnnounceDate	2022-02-17
AnnouncementXML	Submission_2022-02-17_04:21:48.819.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD026335
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Judit Villen
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	phosphorylated residue
Instrument	LTQ Orbitrap Velos; Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2021-05-28 00:16:34	ID requested
⏵ 1	2022-02-17 04:21:49	announced

Whitson JA, Mart, í, n-P, é, rez M, Zhang T, Gaffrey MJ, Merrihew GE, Huang E, White CC, Kavanagh TJ, Qian WJ, Campbell MD, MacCoss MJ, Marcinek DJ, Vill, é, n J, Rabinovitch PS, Elamipretide (SS-31) treatment attenuates age-associated post-translational modifications of heart proteins. Geroscience, 43(5):2395-2412(2021) [pubmed]

submitter keyword: Mouse, heart tissue, aging, SS-31, elamipretide, LC-MS/MS, proteome, phosphoproteome

Judit Villen
contact affiliation	Department of Genome Sciences, University of Washington, Seatte, WA, USA
contact email	jvillen@uw.edu
lab head
Judit Villen
contact affiliation	University of Washington
contact email	jvillen@uw.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD026335

PRIDE project URI

• PRIDE
  1. PXD026335
     1. Label: PRIDE project
     2. Name: Mouse Heart SS-31 Proteome and Phosphoproteome