PXD026315 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Gestational chronodisruption throughout pregnancy impairs adipose tissue physiology in the offspring |
Description | Compelling evidence supports that gestational chronodisruption induces major changes in maternal circadian rhythms, fetal development and that these changes impact adult life at many physiological levels. Using a rat model of chronic photoperiod shifting throughout gestation (CPS), we investigated the detrimental effects of gestational CPS on glucose homeostasis, adipose tissue physiology and metabolism in the adult male offspring. At proteomic level, in CPS adipose tissue, 275 proteins displayed differential expression, compared with LD animals fed with a standard diet. Interestingly, CPS offspring and LD fed with HFD showed 20 proteins in common (2 upregulated 18 downregulated). Based on these common proteins, the IPA analysis found that 2 functional pathways were significantly altered; the network 1 (AKT/ERK) and the network 2 (TNF/IL4). |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-07 |
AnnouncementXML | Submission_2024-10-07_13:40:23.436.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Thilo Kaehne |
SpeciesList | scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116; |
ModificationList | (R)-5-oxo-1,4-tetrahydrothiazine-3-carboxylic acid; deamidated residue; iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-05-27 08:04:09 | ID requested | |
⏵ 1 | 2024-10-07 13:40:24 | announced | |
Publication List
Halabi D, Richter HG, Mendez N, K, ä, hne T, Spichiger C, Salazar E, Torres F, Vergara K, Seron-Ferre M, Torres-Farfan C, Maternal Chronodisruption Throughout Pregnancy Impairs Glucose Homeostasis and Adipose Tissue Physiology in the Male Rat Offspring. Front Endocrinol (Lausanne), 12():678468(2021) [pubmed] |
10.3389/fendo.2021.678468; |
Keyword List
submitter keyword: chronodisruption, adipose tissue physiology, LFQ mass süectrometry |
Contact List
Prof. Dr. Thilo Kaehne |
contact affiliation | University Magdeburg, Medical School Institute of Exptl. Internal Medicine Leipziger STr. 44 39120 Magdeburg, Germany |
contact email | kaehne@med.ovgu.de |
lab head | |
Thilo Kaehne |
contact affiliation | University Magdeburg |
contact email | kaehne@med.ovgu.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD026315
- Label: PRIDE project
- Name: Gestational chronodisruption throughout pregnancy impairs adipose tissue physiology in the offspring