PXD026315-1

PXD026315 is an original dataset announced via ProteomeXchange.

Title	Gestational chronodisruption throughout pregnancy impairs adipose tissue physiology in the offspring
Description	Compelling evidence supports that gestational chronodisruption induces major changes in maternal circadian rhythms, fetal development and that these changes impact adult life at many physiological levels. Using a rat model of chronic photoperiod shifting throughout gestation (CPS), we investigated the detrimental effects of gestational CPS on glucose homeostasis, adipose tissue physiology and metabolism in the adult male offspring. At proteomic level, in CPS adipose tissue, 275 proteins displayed differential expression, compared with LD animals fed with a standard diet. Interestingly, CPS offspring and LD fed with HFD showed 20 proteins in common (2 upregulated 18 downregulated). Based on these common proteins, the IPA analysis found that 2 functional pathways were significantly altered; the network 1 (AKT/ERK) and the network 2 (TNF/IL4).
HostingRepository	PRIDE
AnnounceDate	2024-10-07
AnnouncementXML	Submission_2024-10-07_13:40:23.436.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Thilo Kaehne
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	(R)-5-oxo-1,4-tetrahydrothiazine-3-carboxylic acid; deamidated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2021-05-27 08:04:09	ID requested
⏵ 1	2024-10-07 13:40:24	announced

Halabi D, Richter HG, Mendez N, K, ä, hne T, Spichiger C, Salazar E, Torres F, Vergara K, Seron-Ferre M, Torres-Farfan C, Maternal Chronodisruption Throughout Pregnancy Impairs Glucose Homeostasis and Adipose Tissue Physiology in the Male Rat Offspring. Front Endocrinol (Lausanne), 12():678468(2021) [pubmed]

10.3389/fendo.2021.678468;

submitter keyword: chronodisruption, adipose tissue physiology, LFQ mass süectrometry

Prof. Dr. Thilo Kaehne
contact affiliation	University Magdeburg, Medical School Institute of Exptl. Internal Medicine Leipziger STr. 44 39120 Magdeburg, Germany
contact email	kaehne@med.ovgu.de
lab head
Thilo Kaehne
contact affiliation	University Magdeburg
contact email	kaehne@med.ovgu.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/08/PXD026315

PRIDE project URI

• PRIDE
  1. PXD026315
     1. Label: PRIDE project
     2. Name: Gestational chronodisruption throughout pregnancy impairs adipose tissue physiology in the offspring