PXD026222-1

PXD026222 is an original dataset announced via ProteomeXchange.

Title	Proteomic profiling of young and old mice in the bleomycin model
Description	The most preclinical used in vivo model to study lung fibrosis is the bleomycin-induced lung fibrosis model in 2-3-month-old mice. Although this model resembles key aspects of idiopathic pulmonary fibrosis (IPF), there are limitations in its predictability for the human disease. One of the main differences is the juvenile age of animals that are usually used in experiments, resembling humans of around 20 years. Because IPF patients are usually older than 60 years, aging appears to play an important role in the pathogenesis of lung fibrosis. We here compared young (3 months) and old (21 months) mice 21 days after intratracheal bleomycin instillation.
HostingRepository	PRIDE
AnnounceDate	2024-09-10
AnnouncementXML	Submission_2024-09-10_00:19:10.061.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Daniel Veyel
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; phosphorylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2021-05-24 03:47:50	ID requested
⏵ 1	2024-09-10 00:19:10	announced

Klee S, Picart-Armada S, Wenger K, Birk G, Quast K, Veyel D, Rist W, Violet C, Luippold A, Haslinger C, Thomas M, Fernandez-Albert F, K, ä, stle M, Transcriptomic and proteomic profiling of young and old mice in the bleomycin model reveals high similarity. Am J Physiol Lung Cell Mol Physiol, 324(3):L245-L258(2023) [pubmed]

10.1152/ajplung.00253.2021;

submitter keyword: Bleomycin, idiopathic pulmonary fibrosis, TMT, Fusion Lumos, LC-MS, lung, SPS MS3,C57BL/6J mouse

Wolfgang Rist
contact affiliation	Boehringer Ingelheim Pharma GmbH & Co. KG Drug Discovery Sciences
contact email	wolfgang.rist@boehringer-ingelheim.com
lab head
Daniel Veyel
contact affiliation	Boehringer Ingelheim Pharma GmbH & Co. KG
contact email	daniel.veyel@boehringer-ingelheim.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/09/PXD026222

PRIDE project URI

• PRIDE
  1. PXD026222
     1. Label: PRIDE project
     2. Name: Proteomic profiling of young and old mice in the bleomycin model