PXD026025-1

PXD026025 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	bound proteins of DNA nanomaterials exposed to human serum
Description	DNA aptamers and framework DNA nanostructures are emerging DNA materials with many appealing biological applications including biosensing, bioimaging, drug delivery etc. When placed in physiological fluids, they inevitably encounter biomolecules (majorly proteins) and form complexes that largely affects their biological fate. Nevertheless, little is known regarding the quantitative profile of proteins that adsorb to DNA aptamers and DNA nanostructures in biological environments, and there are no potent strategies to regulate protein profiles. Herein, we performed a proteomic analysis to profile proteins that bind to DNA aptamers (Sgc8c and SYLC3) and nanostructures (a tetrahedral DNA nanostructure and a DNA origami rod) in human serum by using liquid chromatography mass spectrometry (LC-MS).
HostingRepository	MassIVE
AnnounceDate	2021-05-17
AnnouncementXML	Submission_2021-05-17_01:30:02.740.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	FAN XU
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2021-05-15 04:05:56	ID requested
⏵ 1	2021-05-17 01:30:03	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: DNA nanomaterials, protein corona, human serum

submitter keyword: DNA nanomaterials, protein corona, human serum

Contact List

Pengfei Wang
contact affiliation	renji hospital, school of medicine, shanghai jiao tong university
contact email	pengfei.wang@sjtu.com
lab head
FAN XU
contact affiliation	shanghai jiao tong university
contact email	xusiran1990@163.com
dataset submitter

Full Dataset Link List

MassIVE dataset URI
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MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000087433/