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PXD025990-1

PXD025990 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleAn ultrasensitive method for analysis of viral spike N-glycoforms
DescriptionViruses can evade the host immune system by displaying numerous glycans on their surface "spike-proteins" that cover immune epitopes. We have developed an ultrasensitive "single pot" method to assess glycan occupancy and the extent of glycan processing from high-mannose to complex forms at each N-glycosylation site. Though aimed at characterizing glycosylation of viral spike proteins as potential vaccines, this method is applicable for analysis of site-specific glycosylation of any glycoprotein.
HostingRepositoryMassIVE
AnnounceDate2022-08-12
AnnouncementXMLSubmission_2022-08-12_10:31:05.716.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterSabyasachi Baboo
SpeciesList scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; scientific name: BG505 SOSIP.664 MD39; scientific name: BG505 SOSIP.664;
ModificationListHexNAc; Delta:H(1)N(-1)18O(1); Oxidation; 2-pyrrolidone-5-carboxylic acid (Gln)
InstrumentQ Exactive HF-X; timsTOF Pro
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-05-12 20:28:21ID requested
12022-08-12 10:31:06announced
Publication List
no publication
Keyword List
submitter keyword: Proteinase K, N-glycan, heterogeneity, HIV, BG505, Env, viral spike, endoglycosidase
Contact List
John R. Yates III
contact affiliationThe Scripps Research Institute
contact emailjyates@scripps.edu
lab head
Sabyasachi Baboo
contact affiliationThe Scripps Research Institute, La Jolla, CA
contact emailsbaboo@scripps.edu
dataset submitter
Full Dataset Link List
MassIVE dataset URI
Dataset FTP location
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