PXD025904-1

PXD025904 is an original dataset announced via ProteomeXchange.

Title	Systematic analysis of the protein binding networks of TMEM43 and its S358L mutation
Description	Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a severe heart muscle disease leading to sudden cardiac death. The S358L mutation of TMEM43 was first identified in 15 Newfoundland families of ARVC. This mutation is associated with ARVC5, a severe subtype of ARVC with full penetrance and a high percentage of death in patients. Although some studies have revealed that the TMEM43 mutant alters the localization of cardiac proteins, the interaction protein networks of TMEM43 and how the S358L mutation influences the interaction in ARVC remain to be explored. Thus We analyzed the binding partners of TMEM43 and determined the differential interaction proteins of TMEM43 upon S358L mutation.
HostingRepository	iProX
AnnounceDate	2021-05-10
AnnouncementXML	Submission_2021-05-09_21:13:05.668.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yingsi Lu
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2021-05-09 21:11:08	ID requested
⏵ 1	2021-05-09 21:13:06	announced

Dataset with its publication pending

submitter keyword: ARVC,heart,IP-MS

Chengming Zhu
contact affiliation	The Seventh Affiliated Hospital, Sun Yat-sen University
contact email	zhuchm3@mail.sysu.edu.cn
lab head
Yingsi Lu
contact affiliation	The Seventh Affiliated Hospital, Sun Yat-sen University
contact email	luys@mail2.sysu.edu.cn
dataset submitter

iProX dataset URI