PXD025742-1

PXD025742 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	In utero pulse-injection of isotopic amino acids quantifies protein turnover rates during murine fetal development
Description	Protein translational control is a highly regulated step in the gene expression program during development and tools to quantify protein synthesis rates in a developing fetus are lacking. Here, we developed a novel in utero approach to quantify tissue-specific translational kinetics of the nascent proteome during mouse fetal development. The translational kinetic profiles of developing organs displayed differentially expressed protein pathways and synthesis rates which correlated with known physiological changes during mouse development.
HostingRepository	MassIVE
AnnounceDate	2024-06-25
AnnouncementXML	Submission_2024-06-25_09:12:34.477.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Josue Baeza
SpeciesList	scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090;
ModificationList	Acetyl; Oxidation; Carbamidomethyl
Instrument	Q Exactive; Q Exactive HF-X; Orbitrap Fusion

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2021-04-30 07:04:14	ID requested
⏵ 1	2024-06-25 09:12:34	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: protein turnover, pSILAC, pulse-SILAC, pulse chase, development, in utero

submitter keyword: protein turnover, pSILAC, pulse-SILAC, pulse chase, development, in utero

Contact List

Benjamin A. Garcia
contact affiliation	Department of Biochemistry and Biophysics, University of Pennsylvania
contact email	bgarci@mail.med.upenn.edu
lab head
Josue Baeza
contact affiliation	University of Pennsylvania
contact email	baezaj83@gmail.com
dataset submitter

Full Dataset Link List

MassIVE dataset URI
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MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v03/MSV000087342/